床旁肺部超声联合sTREM-1、HMGB1对重症肺炎患者病情严重程度及预后的评估价值  

Bedside Lung Ultrasound Combined with sTREM-1 and HMGB1 in Patients with Severe Pneumonia:Study on their Assessment Value of Disease Severity and Prognosis

作　　者：董敏 贺凌云 徐树 张静 Dong Min;He Lingyun;Xu Shu;Zhang Jing(Department of Critical Care Medicine,Yunyang County People's Hospital,Chongqing 404599,China;Department of Anesthesiology,Yunyang County People's Hospital,Chongqing 404599,China)

机构地区：[1]重庆市云阳县人民医院重症医学科,重庆404599 [2]重庆市云阳县人民医院麻醉科,重庆404599

出　　处：《中外医药研究》2024年第1期144-146,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:研究床旁肺部超声联合可溶性髓系细胞触发受体1(sTREM-1)、高迁移率族蛋白B1(HMGB1)对重症肺炎患者病情严重程度及预后的评估价值。方法:选取2021年10月—2022年12月重庆市云阳县人民医院收治的重症肺炎患者212例作为研究对象,根据入院时急性生理学与慢性健康状况评分系统Ⅱ评分将患者分为危重组(n=98)与非危重组(n=114),根据入院28 d后的生存情况将患者分为生存组与死亡组。比较危重组与非危重组及生存组与死亡组肺部超声评分(LUS)、sTREM-1、HMGB1水平,分析LUS与sTREM-1、HMGB1的相关性。结果:危重组LUS及sTREM-1、HMGB1水平均高于非危重组,差异有统计学意义(P<0.001);死亡组LUS及sTREM-1、HMGB1水平均高于生存组,差异有统计学意义(P<0.001)。Pearson法分析结果显示,LUS与sTREM-1、HMGB1均呈正相关(P<0.05)。结论:床旁肺部超声联合sTREM-1、HMGB1对重症肺炎患者病情严重程度及预后的评估价值较高,临床诊断价值较好,可考虑用于患者的预后研判。Objective:To study the value of bedside lung ultrasound combined with soluble myeloid triggered receptor 1(sTREM-1)and high mobility group protein B1(HMGB1)in assessing the severity and prognosis of patients with severe pneumonia.Meth⁃ods:212 patients with severe pneumonia admitted to Yunyang County People's Hospital in Chongqing from October 2021 to De⁃cember 2022 were selected as the study subjects,and the patients were categorized into the critical group(n=98)and the noncritical group(n=114)based on the Acute Physiology and Chronic Health Evaluation II scoring system at hospital admission.Fur⁃thermore the patients were classified into the survival group and death group based on their survival status 28 days after admis⁃sion.Lung ultrasound score(LUS),sTREM-1,and HMGB1 levels were compared between the critical and non-critical groups and also between the survival and death groups,and the correlation between LUS and sTREM-1 and HMGB1 was analyzed.Results:The levels of LUS and sTREM-1,HMGB1 in the critical group were higher than those in the non-critical group,with statistically significant differences(P<0.001);the levels of LUS and sTREM-1,HMGB1 in the death group were higher than those in the sur⁃vival group,with statistically significant differences(P<0.001).The results of the analysis of Pearson's method showed that the cor⁃relations between LUS and sTREM-1,HMGB1 were positively correlated(P<0.05).Conclusion:Bedside lung ultrasound com⁃bined with sTREM-1 and HMGB1 has a high value in assessing the severity and prognosis of patients with severe pneumonia,which has a good clinical diagnostic value and can be considered for prognostic studies.

关 键 词：床旁肺部超声 可溶性髓系细胞触发受体1 高迁移率族蛋白B1 重症肺炎 预后 

分 类 号：R445.1[医药卫生—影像医学与核医学] R563.1[医药卫生—诊断学]