疱疹病毒利用宿主蛋白高效复制机理及其抑制剂研究进展  

Advances in Mechanism of Herpesvirus Efficient Replication Utilizing Host Proteins and Its Inhibitors

作　　者：田文骏 游婧铃 王晓佳[1] TIAN Wenjun;YOU Jingling;WANG Xiaojia(College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业大学动物医学院,北京海淀100193

出　　处：《中国兽医杂志》2024年第3期90-96,共7页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金项目(32172821)。

摘　　要：疱疹病毒的入侵、转录和蛋白合成等多个生命活动,都需要利用宿主细胞蛋白和微环境进行。该过程一般会导致细胞蛋白的合成和降解、修饰、细胞定位改变,以及与其他蛋白相互作用等一系列变化。本文从病毒感染引起的细胞凋亡和自噬体系、泛素-蛋白酶体系、核-质转运体系、生物合成体系和病毒诱导的先天免疫反应几个层面,综述病毒劫持或干扰细胞正常生命活动的研究进展,探讨病毒与宿主细胞的相互作用关系,并对目前抗疱疹病毒药物靶点和机制进行总结,以期为设计新型抗病毒制剂提供资料。Various life activities of herpesviruses,such as invasion,transcription,and protein synthesis,rely on the utilization of host cell proteins and microenvironments.This process generally leads to a series of changes,including the synthesis and degradation of cellular proteins,modifications,cellular localization,and interactions with other proteins.This article reviews the research progress of virus hijacking or interfering with normal activities of cells and discussed the interaction between virus and host cell from the aspects of virus-induced cellular apoptosis and autophagy systems,ubiquitin-proteasome systems,nucleocytoplasmic transport systems,biosynthesis systems,and virus-induced innate immune responses,and summarizes the current targets and mechanisms of anti-herpesvirus drugs,aiming to provide information for the design of novel antiviral agents.

关 键 词：疱疹病毒 细胞凋亡 细胞自噬 核质转运 蛋白翻译 抗病毒药物 

分 类 号：S855.3[农业科学—临床兽医学]