Deblurring,artifact-free optical coherence tomography with deconvolution-random phase modulation  

作　　者：Xin Ge Si Chen Kan Lin Guangming Ni En Bo Lulu Wang Linbo Liu 

机构地区：[1]School of Electrical and Electronic Engineering,Nanyang Technological University,Singapore 639798,Singapore [2]School of Chemical and Biomedical Engineering,Nanyang Technological University,Singapore 637459,Singapore [3]China-Singapore International Joint Research Institute(CSIJRI),Guangzhou 510000,China [4]School of Optoelectronic Science and Engineering,University of Electronic Science and Technology of China,Chengdu 610054,China

出　　处：《Opto-Electronic Science》2024年第1期13-24,共12页光电科学（英文）

基　　金：supported by the Guangdong Natural Science Fund General Program (2023A1515011289);Singapore Ministry of Health's National Medical Research Council under its Open Fund Individual Research Grant (MOH-OFIRG19may-0009);Ministry of Education Singapore under its Academic Research Fund Tier 1 (RG35/22);Academic Research Funding Tier 2 (MOE-T2EP30120-0001);China-Singapore International Joint Research Institute (203-A022001).

摘　　要：Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods.Unfortu-nately,its application in optical coherence tomography(OCT)is often hindered by sensitivity to noise,which leads to ad-ditive ringing artifacts.These artifacts considerably degrade the quality of deconvolved images,thereby limiting its effect-iveness in OCT imaging.In this study,we propose a framework that integrates numerical random phase masks into the deconvolution process,effectively eliminating these artifacts and enhancing image clarity.The optimized joint operation of an iterative Richardson-Lucy deconvolution and numerical synthesis of random phase masks(RPM),termed as De-conv-RPM,enables a 2.5-fold reduction in full width at half-maximum(FWHM).We demonstrate that the Deconv-RPM method significantly enhances image clarity,allowing for the discernment of previously unresolved cellular-level details in nonkeratinized epithelial cells ex vivo and moving blood cells in vivo.

关 键 词：DECONVOLUTION random phase masks DEBLURRING 

分 类 号：O439[机械工程—光学工程] TP391.41[理学—光学]