毛细支气管炎患儿IL-33、Eotaxin、sCD163水平对喘息反复发作的预测价值  

Predictive value of IL-33,Eotaxin and sCD163 levels for recurrent wheezing in children with bronchiolitis

作　　者：徐雨歆 李扬 罗程程 XU Yuxin;LI Yang;LUO Chengcheng(Department of Child Healthcare,Jiamusi Maternal and Child Health Hospital,Jiamusi,Heilongjiang 154002,China;Department of Pediatrics,Shuangyashan Maternal and Child Health Hospital,Shuangyashan,Heilongjiang 154000,China)

机构地区：[1]佳木斯市妇幼保健院儿童保健科,黑龙江佳木斯154002 [2]双鸭山市妇幼保健院儿内科,黑龙江双鸭山154000

出　　处：《国际检验医学杂志》2024年第6期647-652,共6页International Journal of Laboratory Medicine

基　　金：黑龙江省教育厅科学技术研究项目(14251775)。

摘　　要：目的探讨毛细支气管炎患儿白细胞介素-33(IL-33)、嗜酸性粒细胞趋化因子(Eotaxin)、可溶性清道夫受体CD163(sCD163)水平对喘息反复发作的预测价值。方法将2019年8月至2021年10月于佳木斯市妇幼保健院就诊的120例毛细支气管炎患儿纳入研究。收集患儿临床资料,包括人口学因素、出生学因素、有无特应性因素、住院时间、从出现症状至就诊时间、呼吸窘迫评估工具(RDAI)评分。检测患儿呼吸道合胞病毒(RSV)、鼻病毒(RV)感染情况。采集患儿血液标本进行检测。血液检测指标包括总免疫球蛋白E(IgE)、白细胞计数(WBC)、IL-33、Eotaxin、sCD163。对出院患儿进行1年随访,按喘息发作次数分为非反复组和反复组。比较两组患儿临床资料及血液检测指标水平。采用Logistic回归分析毛细支气管炎患儿喘息反复发作的危险因素。采用Pearson相关分析血液检测指标与RDAI评分的相关性。绘制受试者工作特征(ROC)曲线,分析IL-33、Eotaxin、sCD163水平单独及联合预测毛细支气管炎患儿喘息反复发作的价值。结果反复组RDAI评分、有湿疹史者所占比例、有个人过敏史者所占比例、RSV感染率均高于非反复组(P<0.05)。反复组IL-33、Eotaxin、sCD163水平高于非反复组(P<0.05)。Pearson相关分析发现,毛细支气管炎患儿IL-33、Eotaxin、sCD163水平与RDAI评分呈正相关(r=0.516、0.611、0.522,P<0.05)。Logistic回归分析显示,RDAI评分、湿疹史、个人过敏史、RSV感染、IL-33水平升高、Eotaxin水平升高、sCD163水平升高是毛细支气管炎患儿喘息反复发作的危险因素(OR>1,P<0.05)。ROC曲线结果显示,IL-33、Eotaxin、sCD163水平单独及联合预测毛细支气管炎患儿喘息反复发作发生的曲线下面积(AUC)为0.829(95%CI:0.757~0.901)、0.858(95%CI:0.794~0.922)、0.857(95%CI:0.789~0.925)、0.954(95%CI:0.921~0.987)。结论毛细支气管炎患儿IL-33、Eotaxin、sCD163水平升高会增加喘息�Objective To investigate the predictive value of interleukin-33(IL-33),eosinophil chemotactic factor(Eotaxin),soluble scavenger receptor CD163(sCD163)for recurrent wheezing in children with bronchiolitis.Methods A total of 120 children with bronchiolitis who were treated in Jiamusi Maternal and Child Health Hospital from August 2019 to October 2021 were enrolled in the study.The clinical data of the children were collected,including demographic factors,birth factors,atopic factors,length of hospital stay,time from symptom onset to visit,and respiratory distress assessment tool(RDAI)score.Respiratory syncytial virus(RSV)and rhinovirus(RV)were detected.Blood samples were collected for detection.Blood test indicators included total immunoglobulin E(IgE),white blood cell count(WBC),IL-33,Eotaxin and sCD163.The discharged children were followed up for 1 year,and they were divided into non-recurrent group and recurrent group according to the number of wheezing episodes.The two groups were compared in terms of clinical data and blood test indicators.Logistic regression was used to analyze the risk factors for recurrent wheezing in children with bronchiolitis.Pearson correlation analysis was used to analyze the correlation between blood test indexes and RDAI score.The receiver operating characteristic(ROC)curve was drawn to analyze the value of IL-33,Eotaxin,and sCD163 levels alone and in combination in predicting recurrent wheezing in children with bronchiolitis.Results Compared with the non-recurrent group,the recurrent group had significantly higher RDAI score,higher proportion of patients with a history of eczema,a personal history of allergy,and a significantly higher RSV infection rate(P<0.05).The recurrent group had significantly higher levels of IL-33,Eotaxin,and sCD163 than the non-recurrent group(P<0.05).Pearson correlation analysis showed that the levels of IL-33,Eotaxin,and sCD163 in children with bronchiolitis were positively correlated with RDAI score(r=0.516,0.611,0.522,P<0.05).Logistic regression analysis

关 键 词：毛细支气管炎 喘息反复发作 白细胞介素-33 嗜酸性粒细胞趋化因子 可溶性清道夫受体CD163 

分 类 号：R446.11[医药卫生—诊断学]