血清Nesfatin-1、25(OH)D_(3)水平对儿童癫痫持续状态短期预后的预测价值  

The predictive value of serum Nesfatin-1 and 25(OH)D_(3)levels for the short-term prognosis of status epilepticus in children

作　　者：李影明 袁玉 曲红亮 王曼卿 LI Yingming;YUAN Yu;QU Hongliang;WANG Manqing(Department of Pediatrics,Jiamusi Maternal and Child Health Care Hospital,Jiamusi,Heilongjiang 154000,China)

机构地区：[1]佳木斯市妇幼保健院儿科,黑龙江佳木斯154000

出　　处：《国际检验医学杂志》2024年第6期676-680,共5页International Journal of Laboratory Medicine

基　　金：黑龙江省卫生健康委科研课题项目(2019-358)。

摘　　要：目的探讨血清人新饱食分子蛋白-1(Nesfatin-1)、25-羟基维生素D_(3)[25(OH)D_(3)]水平对儿童癫痫持续状态(SE)短期预后的预测价值。方法将该院2020年3月至2023年3月收治的104例SE患儿纳入研究,收集患儿临床资料,根据其出院时采用格拉斯哥预后评分量表(GOS)进行评分的结果分为预后良好组(等于5分)与预后不良组(<5分)。采用单因素分析和多因素Logistic回归分析血清Nesfatin-1、25(OH)D_(3)水平是否为儿童SE短期预后不良的危险因素。绘制受试者工作特征(ROC)曲线分析血清Nesfatin-1、25(OH)D_(3)水平对儿童SE短期预后不良的预测价值。结果出院时,85例患儿GOS评分为5分,占81.73%(85/104),纳入预后良好组;19例患儿GOS<5分,占18.27%(19/104),纳入预后不良组。两组患儿性别、年龄、既往癫痫病史、癫痫发作类型比较,差异无统计学意义(P>0.05)。SE发作时间、用药至发作停止时间、脑电图结果、头颅CT结果、血清Nesfatin-1、25(OH)D_(3)水平比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,SE发作时间>60 min、头颅CT结果异常、血清Nesfatin-1、25(OH)D_(3)水平是儿童SE短期预后不良的独立危险因素(OR=1.945、2.343、1.731、1.505,P<0.05);血清Nesfatin-1、25(OH)D_(3)水平联合预测儿童SE短期预后不良的ROC曲线下面积为0.840(95%CI:0.732~0.949),优于血清Nesfatin-1、25(OH)D_(3)水平单项预测[0.607(95%CI:0.453~0.761)、0.742(95%CI:0.604~0.880)]。结论血清Nesfatin-1、25(OH)D_(3)水平是儿童SE预后不良的危险因素,二者联合预测儿童SE预后不良有较高的预测价值。Objective To investigate the predictive value of serum Nesfatin-1 and 25-hydroxyvitamin D_(3)[25(OH)D_(3)]levels for the short-term prognosis of status epilepticus(SE)in children.Methods A total of 104 children with SE admitted to the hospital from March 2020 to March 2023 were enrolled in the study,and the clinical data of the children were collected.According to the Glasgow outcome Scale(GOS)score at discharge,the children were divided into a good prognosis group(equal to 5 points)and a poor prognosis group(<5 points).Univariate analysis and multivariate Logistic regression were used to analyze whether serum Nesfatin-1 and 25(OH)D_(3)levels were risk factors for poor short-term prognosis in children with SE.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum Nesfatin-1 and 25(OH)D_(3)levels for the short-term poor prognosis in children with SE.Results At discharge,85 children[81.73%(85/104)]with a GOS score of 5 were included in the good prognosis group,and 19 children[8.27%(19/104)]with a GOS score of<5 were included in the poor prognosis group.There was no significant difference in gender,age,previous history of epilepsy,and seizure types between the two groups(P>0.05).There were significant differences in the duration of SE,the time from medication to seizure cessation,electroencephalogram(EEG)results,head CT results,and serum Nesfatin-1 and 25(OH)D_(3)levels between the two groups(P<0.05).Multivariate Logistic regression analysis showed that SE duration>60 min,abnormal head CT results,serum Nesfatin-1 and 25(OH)D_(3)levels were independent risk factors for the short-term poor prognosis of children with SE(OR=1.945,2.343,1.731,1.505;P<0.05).The area under the ROC curve of serum Nesfatin-1 and 25(OH)D_(3)levels combined to predict poor short-term prognosis of children with SE was 0.840(95%CI:0.732-0.949),which was better than that of serum Nesfatin-1 and 25(OH)D_(3)levels alone[0.607(95%CI:0.453-0.761),0.742(95%CI:0.604-0.880)],respectively.Conclusion Serum Nesfa

关 键 词：血清Nesfatin-1 25-羟基维生素D_(3) 持续癫痫状态 儿童 

分 类 号：R446.11[医药卫生—诊断学] R742.1[医药卫生—临床医学]