317例肺结核患者中断治疗影响因素分析  

Analysis of influencing factors on treatment interruption in 317 pulmonary tuberculosis patients

作　　者：郑海伦 李亚敏 孙闪华 贺晓新 Zheng Hailun;Li Yamin;Sun Shanhua;He Xiaoxin(Tuberculosis Outpatient Department,Beijing Center for Disease Control and Prevention,Beijing 100035,China;Institute of Tuberculosis Prevention and Control,Beijing Center for Disease Control and Prevention,Beijing 100035,China;Beijing Center for Disease Control and Prevention,Beijing 100013,China)

机构地区：[1]北京市疾病预防控制中心结核病门诊部,北京100035 [2]北京市疾病预防控制中心结核病预防控制所,北京100035 [3]北京市疾病预防控制中心,北京100013

出　　处：《中国防痨杂志》2024年第4期467-472,共6页Chinese Journal of Antituberculosis

基　　金：首都卫生发展科研专项(首发2018-2-3021)。

摘　　要：目的:分析317例肺结核患者中断治疗情况及影响因素,并提出相应对策,为提升肺结核患者管理质量提供依据。方法:以北京市疾病预防控制中心结核病门诊部2012—2021年登记管理的2715例肺结核患者为研究对象,收集“中国疾病预防控制信息系统”的子系统“结核病管理信息系统”和门诊病案记录中的人口学信息及临床诊疗信息,分析肺结核患者中断治疗情况,采用单因素和多因素非条件logistic回归方法分析中断治疗的影响因素。结果:2715例肺结核患者中,中断治疗患者317例,中断治疗率为11.68%。单因素分析结果显示,女性患者的中断治疗率(10.11%,109/1078)低于男性患者(12.71%,208/1637),差异有统计学意义(χ^(2)=4.244,P=0.039);25~44岁组肺结核患者的中断治疗率(8.21%,96/1170)低于<25岁组(11.38%,57/501)、45~64岁组(14.75%,86/583)和≥65岁组(16.92%,78/461),差异有统计学意义(χ^(2)=31.349,P<0.001);职业分类中,学生/教师/医务人员/干部职员肺结核患者的中断治疗率(7.29%,72/988)低于农民/民工/工人(13.37%,25/187)、离退休/家务及待业/其他(14.65%,194/1324)和商业、餐饮服务/公共场所服务员(12.04%,26/206)的患者,差异有统计学意义(χ^(2)=30.373,P<0.001);初治肺结核患者中断治疗率(11.05%,274/2480)低于复治肺结核患者(18.30%,43/235),差异有统计学意义(χ^(2)=10.939,P<0.001)。多因素分析结果显示,与25~44岁组患者相比较,<25岁组(OR=1.536,95%CI:1.082~2.180)、45~64岁组(OR=1.538,95%CI:1.101~2.149)和≥65岁组(OR=1.596,95%CI:1.095~2.326)更容易发生中断治疗;与学生/教师/医务人员/干部职员相比较,商业、餐饮服务/公共场所服务员(OR=1.693,95%CI:1.050~2.731)、农民/民工/工人(OR=1.681,95%CI:1.014~2.787)、离退休/家务及待业/其他职业(OR=1.776,95%CI:1.278~2.469)的患者更容易发生中断治疗;复治患者比初治患者更容易发生中断治疗(OR=1.487,95%CI:1.031~2.145)。在疗程的前2个Objective:To analyze the interruption of treatment and influencing factors in 317 patients with pulmonary tuberculosis,then propose countermeasures to provide basis for improving the management quality of tuberculosis patients.Methods:All of 2715 pulmonary tuberculosis patients were taken as the research objects,who were registered and managed in Tuberculosis Outpatient Department of Beijing Center for Disease Control and Prevention from 2012 to 2021.Basic demographic information and clinical data was collected from Tuberculosis Management Information System and medical records respectively.Univariate and multivariate logistic regression methods were used to analyze the influencing factors of treatment interruption.Results:Among 2715 pulmonary tuberculosis patients,317 cases were interrupted treatment,with a rate of 11.68%.Univariate analysis showed that the interrupted treatment rate of female patients(10.11%,109/1078)was lower than that of male patients(12.71%,208/1637),and there was significant difference(χ^(2)=4.244,P=0.039).The interrupted treatment rate of patients in 25-44 years old group(8.21%,96/1170)was lower than that in<25 years old group(11.38%,57/501),45-64 years old group(14.75%,86/583)and≥65 years old group(16.92%,78/461),and the difference was significant(χ^(2)=31.349,P<0.01).In occupational classification,the interrupted treatment rate for tuberculosis patients with occupations as students/teachers/medical personnel/cadres(7.29%,72/988)was lower than that of patients with occupations as farmers/migrant workers/workers(13.37%,25/187),retired/housework and unemployed/other(14.65%,194/1324),and commercial,catering service/public place waiters(12.04%,26/206)and the difference was statistically significant(χ^(2)=30.373,P<0.001).The interrupted treatment rate of initially treated pulmonary tuberculosis patients(11.05%,274/2480)was lower than that in retreated pulmonary tuberculosis patients(18.30%,43/235),and the difference was statistically significant(χ^(2)=10.939,P<0.001).Multivariate analysi

关 键 词：结核 肺 病例管理 因素分析 统计学 中断治疗 

分 类 号：R521[医药卫生—内科学]