丙卡特罗联合多索茶碱治疗支气管哮喘急性发作期的临床研究  

Clinical study on doxophylline combined with procaterol in treatment of acute attack of bronchial asthma

作　　者：贾要丽 JIA Yaoli(Department of Respiratory,Henan Province Chest Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省胸科医院呼吸内科,河南郑州450000

出　　处：《现代药物与临床》2024年第2期377-381,共5页Drugs & Clinic

摘　　要：目的探讨丙卡特罗联合多索茶碱治疗支气管哮喘急性发作期的临床疗效。方法选取2021年8月—2023年8月呼吸科收治的支气管哮喘急性发作期患者128例,随机分为对照组(64例)和治疗组(64例)。对照组患者静脉滴注多索茶碱注射液,300 mg加入生理盐水100 mL,1次/d。在对照组的基础上,治疗组口服盐酸丙卡特罗颗粒,50μg/次,3次/d;两组治疗10 d。观察两组患者临床疗效,比较治疗前后两组患者临床症状恢复时间,哮喘控制测试量表(ACT)评分,血清半胱氨酰白三烯(Cys-LTs)、嗜酸性粒细胞趋化因子(Eotaxin)、白细胞介素-6(IL-6)和血小板衍生生长因子(PDGF-BB)水平。结果治疗后,治疗组临床总有效率为98.44%,明显高于对照组总有效率(84.38%,P<0.05)。治疗后,治疗组症状恢复时间均明显早于对照组(P<0.05)。治疗后,两组患者ACT评分比治疗前明显升高(P<0.05),且治疗组患者ACT评分明显高于对照组(P<0.05)。治疗后,两组患者血清Cys-LTs、Eotaxin、IL-6、PDGF-BB水平比治疗前明显降低(P<0.05),且治疗组水平均明显低于对照组(P<0.05)。结论丙卡特罗与多索茶碱协同治疗,可有效改善哮喘发作期症状,增强哮喘控制能力,降低局部炎性因子含量。Objective To explore the clinical effect of doxophylline combined with procaterol in treatment of acute attack of bronchial asthma.Methods Patients(128 cases)with acute attack of bronchial asthma in Henan Province Chest Hospital from August 2021 to August 2023 were randomly divided into control(64 cases)and treatment(64 cases)group.Patients in the control group were iv administered with Doxofylline Injection,300 mg added into normal saline 100 mL,once daily.Patients in the treatment group were po administered with Procaterol Hydrochloride Granules on the basis of the control group,50μg/time,three times daily.Patients in two groups were treated for 10 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,ACT scores,the levels of serum Cys-LTs,Eotaxin,IL-6 and PDGF-BB in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.44%,which was significantly higher than that of the control group(84.38%,P<0.05).After treatment,the recovery time of symptoms in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the ACT score in two groups was significantly higher than that before treatment(P<0.05),and the ACT score in the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the serum levels of Cys-LTs,Eotaxin,IL-6 and PDGF-BB in two groups were significantly lower than those before treatment(P<0.05),and the levels in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The combined treatment of procaterol and doxophylline can effectively improve the symptoms of asthma attack,enhance the ability of asthma control and reduce the content of local inflammatory factors.

关 键 词：多索茶碱注射液 盐酸丙卡特罗颗粒 支气管哮喘急性发作期 哮喘控制测试量表 半胱氨酰白三烯 嗜酸性粒细胞趋化因子 

分 类 号：R974[医药卫生—药品]