体质毒理学:中药安全性评价的新方向  

Constitution-Based Toxicology:A New Perspective of Study for Assessing the Safety of Traditional Chinese Medicine

作　　者：刘传鑫 孔娇 Liu Chuanxin;Kong Jiao(Henan Key Laboratory of Rare Diseases,Endocrinology and Metabolism Center,the First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang471003,China;Laboratory of Drug Metabolism and Pharmaceutical Analysis,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心、河南省罕见病重点实验室,洛阳471003 [2]浙江大学药学院药物代谢和药物分析研究所,杭州310058

出　　处：《世界科学技术-中医药现代化》2023年第12期3776-3784,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金青年科学基金项目(82204938):基于“毒理证据链”解析八角莲致肝损伤的“证-量-毒”关系与体内毒性传递路径,负责人:刘传鑫。

摘　　要：目前中药安全性研究主要依照现代医学体系,忽视了机体因素在不良事件中发生的关键性。因此本文提出以“体-药互斥”为内核,以“辨体-辨病-辨证”模式和“中药药性理论”为指导,以“毒理证据链”为方法,以药物警戒理论为根基,由先进分析技术支撑的研究思路——基于“辨体论忌”的体质毒理学,为促进中药安全性评价系统的构建提供参考。At present,research on the safety of traditional Chinese medicine mainly follows the modern medical system,neglecting the crucial role of body factors in adverse events.This research first proposed a new way of thinking about"Constitution-based toxicology"research based on"Contraindication with Constitution differentiation",with"constitutional-herb mutual exclusion"as the core,guided by"Constitution differentiation-disease differentiationsyndrome differentiation"and"Properties Theory of Chinese Medicinal Herbs",with the"toxicological evidence chain"as the method,the pharmacovigilance theory as the foundation,and supported by advanced analytical technology.Constitution-based toxicology,a new interdisciplinary field combining TCM toxicology and TCM constitution theory,is a novel advancement of traditional Chinese medicine.It offers the groundwork for advancing the methodical design of traditional Chinese medicine safety evaluation.

关 键 词：体质毒理学 辨体论忌 辨体-辨病-辨证 毒理证据链 中药安全性评价 

分 类 号：R285[医药卫生—中药学]