基于细胞程序性死亡机制及炎性反应探讨中药诱发的有害结局  

To Explore the Harmful Outcomes Induced by Traditional Chinese Medicine Based on the Mechanism of Programmed Cell Death and Inflammatory Response

作　　者：李映 申佰轩 李文鲜 王佳琳 郭源辉 刘传鑫 Li Ying;Shen Baixuan;Li Wenxian;Wang Jialin;Guo Yuanhui;Liu Chuanxin(Department of Pharmacy,First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China;Endocrine and Metabolic Disease Center,First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology,Henan Laboratory of Rare Diseases,Luoyang 471003,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院药学部,洛阳471003 [2]河南科技大学临床医学院、河南科技大学第一附属医院内分泌代谢中心、河南省罕见病实验室,洛阳471003 [3]北京中医药大学中药学院,北京100029

出　　处：《世界科学技术-中医药现代化》2023年第12期3797-3807,共11页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年科学基金项目(82204938):基于“毒理证据链”解析八角莲致肝损伤的“证-量-毒”关系与体内毒性传递路径;负责人:刘传鑫。

摘　　要：目的本文通过联合细胞程序性死亡机制和炎性反应阐述中药诱发的有害作用及机制,期望为中药合理用药及毒理学研究提供数据支持和理论参考。方法通过系统分析细胞死亡与炎性反应相关性,总结归纳国内外对细胞焦亡、程序性细胞坏死及铁死亡的分子机制,进一步探讨中药诱发的有害结局。结果不同的有毒中药及其活性成分对生物机体耐受不同,细胞程序性死亡是中药致毒的重要分子机制,其信号通路复杂多样且多伴随炎性反应的发生,二者对中药产生毒性作用存在一定影响。结论中药可通过细胞死亡为炎性反应通路提供炎性介质或改变细胞生理平衡状态,进而诱发炎症级联反应并促进机体各系统在细胞死亡和炎性反应双重影响下产生有害结局。Objective In this paper,the harmful effects and mechanisms induced by traditional Chinese medicine were expounded by combining the mechanism of programmed cell death and inflammatory reaction.It is expected to provide data support and theoretical reference for the rational use of traditional Chinese medicine and toxicology research.Methods By systematically analyzing the correlation between cell death and inflammatory response,the molecular mechanisms of pyroptosis,programmed cell necrosis and ferroptosis at home and abroad were summarized,and the harmful outcomes induced by traditional Chinese medicine were further discussed.Results Different toxic traditional Chinese medicines and their active ingredients have different tolerances to biological organisms.Programmed cell death is an important molecular mechanism for the toxicity of traditional Chinese medicines.Its signaling pathways are complex and diverse and are often accompanied by inflammatory reactions.Both of them have a certain effect on the toxic effects of traditional Chinese medicine.Conclusion Traditional Chinese medicine can provide inflammatory mediators for inflammatory response pathways through cell death or change the physiological balance of cells,thereby inducing inflammatory cascade reactions and promoting harmful outcomes in various systems of the body under the dual effects of cell death and inflammatory response.

关 键 词：中药毒性 炎性反应 细胞程序性死亡 细胞焦亡 程序性坏死 铁死亡 

分 类 号：R285[医药卫生—中药学]