拮抗剂方案鲜胚移植结合选择性单胚移植的临床效果观察  

Clinical observation of the combined effect of antagonist protocol with fresh embryo transfer and selective single embryo transfer

作　　者：黄园斐 罗龙丹 丁书芳 高晶 何柏松 叶天民 HUANG Yuanfei;LUO Longdan;DING Shufang;GAO Jing;He Pakchung;Ye Tianmin(Center for Reproductive Medicine and Key Laboratory of Fertility Regulation of The University of Hong Kong,Shenzhen Hospital,518053,China)

机构地区：[1]香港大学深圳医院生殖医学中心,518053 [2]中山大学附属第三医院生殖医学中心

出　　处：《中国生育健康杂志》2024年第2期142-146,共5页Chinese Journal of Reproductive Health

摘　　要：目的探讨以单胚胎移植为主的体外受精-胚胎移植(IVF-ET)治疗策略结局与应用的可行性。方法选取2015年10月至2020年12月于本院生殖中心接受IVF-ET治疗的不孕患者1096例进行回顾性分析。采用拮抗剂方案促排卵新鲜胚胎移植治疗,根据其移植胚胎数及胚胎发育时间分为A、B、C三组,A组第二天胚胎单胚胎移植(n=566),B组第二天胚胎双胚胎移植(n=410),C组第五天胚胎单胚胎移植(n=120),对三组妊娠结局及并发症进行对比分析。结果A组与B组的临床妊娠率(30.0%vs.33.1%)、活产率(23.6%vs.23.6%)差异均无统计学意义,C组与B组的临床妊娠率(40.0%vs.33.1%)差异无统计学意义,C组与B组的活产率(33.3%vs.23.6%)差异有统计学意义,A组与C组的临床妊娠率(30.0%vs.40.0%)、活产率(23.6%vs.33.3%)差异均有统计学意义。结论本中心实行的单胚胎移植为主拮抗剂方案是安全有效的策略,双胎移植并未显著提高移植的临床妊娠率及活产妊娠率。Objective To investigate the feasibility of single embryo transfer-based IVF-ET treatment strategy outcomes and applications.Methods A total of 1096 infertile patients who received IVF-ET treatment in the reproductive center of our hospital from October 2015 to December 2020 were retrospectively analyzed.Ovulation induction fresh embryo transfer treatment was used by antagonist regimen,which was divided into 3 groups according to the number of embryos transferred and the time of embryo development:group A,the next day embryo single embryo transfer(n=566);group B,second day embryo double embryo transfer(n=410);and group C,fifth day embryo single embryo transfer(n=120).Pregnancy outcomes and complications were compared across the three groups.Results There were no significant differences in the clinical pregnancy rate(30.0%vs.33.1%)and live birth rate(23.6%vs.23.6%)between group A and group B.There was no significant difference in the clinical pregnancy rate between group C and group B(40.0%vs.33.1%).There was a statistically significant difference in live birth rate between group C and group B(33.3%vs.23.6%).There were significant differences in the clinical pregnancy rate(30.0%vs.40.0%)and live birth rate(23.6%vs.33.3%)between group A and group C.Conclusion The single embryo transfer as the main antagonist regimen is a safe and effective strategy,and twin transfer does not significantly improve the clinical pregnancy rate and live birth pregnancy rate of transplantation.

关 键 词：IVF-ET 单胚胎移植 活产妊娠率 临床妊娠率 临床并发症 

分 类 号：R71[医药卫生—妇产科学]