从“整合论治”策略探析痛风病防治中药研发新路径  

Exploration on the new path for developing anti-gout disease Chinese medicine from the perspective of‘integrated therapy’strategy

作　　者：王雨[1] 林志健[1] 李文静 黄晶 褚梦真 胥亦 张冰[1] WANG Yu;LIN Zhijian;LI Wenjing;HUANG Jing;CHU Mengzhen;XU Yi;ZHANG Bing(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《中华中医药杂志》2024年第2期576-580,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金联合基金项目(No.U20A20406),国家自然科学基金青年科学基金项目(No.82104475);国家科技重大专项重大新药创制(No.2017ZX09301024);国家中医药领军人才支持计划“岐黄学者”项目(No.1040063320004)。

摘　　要：痛风病是与高血尿酸、尿酸盐沉积密切相关的尿酸代谢病,具有进展性、反复性、高发性,中医药在其临床防治中独具优势。本课题组立足中医药临床优势,追踪现代研究前沿,总结多年临床及基础研究,认为应全局性、整体性地认知痛风病,创新性地提出“痛风病”新概念,建立了病症-病程-病机-功效多方位整合的中医药“整合论治”痛风病临床策略,并在“整合论治”策略指导下创建了具备“特色模型-特定器官-特征成分-定向靶点-综合效用评价”五模块的痛风病防治中药研发平台,进行了创新中药示例研究,从而形成了“整合论治”痛风病创新中药研发的新路径。该路径的探索不仅是中药治疗特色的挖掘与拓展,亦是中医药防治尿酸代谢病的高水平传承与创新发展,可为中医药临床优势的创新实践应用及现代化发展提供参考借鉴。Gout disease is a metabolic disease closely related to hyperuricemia and urate crystal deposition.It has the characteristics of progressive,repetitive,and high incidence.Based on the clinical advantages of traditional Chinese medicine(TCM),we believe that gout disease should be recognized comprehensively and holistically,and we innovatively propose the concept of‘gout disease’by tracking the research frontiers and summarizing years of clinical and basic studies.Then,we proposed the‘integrated therapy’strategy of TCM for treating gout disease.This clinical strategy integrates disease symptoms,progression,pathogenesis,and drug efficacy in multiple directions.Under the guidance of this strategy,we further established an innovative traditional Chinese drug research and development platform for treating gout disease.This platform has five modules of‘characteristic models,specific organs,characteristic components,directional targets,and comprehensive utility evaluation’.Furthermore,we carried out example studies of innovative traditional Chinese materia medica.Therefore,we formed a new path for developing innovative traditional Chinese materia medica for treating gout disease characteristics with‘integrated therapy’.This practice explores and expands the clinical advantages of traditional Chinese materia medica and exhibits a highlevel inheritance and innovative development of TCM.We hope it will provide a reference for the creative practice and modern application development of the clinical advantages of TCM.

关 键 词：痛风病 “整合论治”策略 创新中药 新路径 尿酸代谢病 

分 类 号：R259[医药卫生—中西医结合]