反复急性加重的支气管扩张症58例患者临床特征及中医证候的相关性研究  

Correlation study on clinical characteristics and traditional Chinese medicine syndromes of 58 bronchiectasis patients with frequent acute exacerbation

作　　者：宗慧琪 胡哲恺 王冰[3] 袁沙沙[3] 赵媛 张子健 苗青[3] ZONG Huiqi;HU Zhekai;WANG Bing;YUAN Shasha;ZHAO Yuan;ZHANG Zijian;MIAO Qing(Beijing University of Chinese Medicine,Beijing 100029,China;Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院广安门医院,北京100053 [3]中国中医科学院西苑医院,北京100091

出　　处：《中华中医药杂志》2024年第2期1044-1048,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国中医科学院科技创新工程(No.CI2021A01101,No.CI2021A01103)。

摘　　要：目的:通过对支气管扩张症患者进行横断面调查,分析1年内急性加重次数患者的临床特征及中医证候分布的相关性。方法:选取2021年4年—2022年3月中国中医科学院西苑医院肺病科门诊与病房的支气管扩张症患者120例,分析1年内急性加重的次数与患者支气管扩张严重指数(BSI)、呼吸症状评分、改良医学研究委员会呼吸困难量表(mMRC)、肺功能、支扩病程、焦虑和抑郁量表评分、痰培养PA、肺CT等的相关性,并将患者分成两组比较,从而探讨中医证型分布规律。结果:120例支气管扩张症患者中反复加重组58例(48.33%),非反复加重组62例(51.67%),Spearman相关性分析结果显示:患者1年内急性加重次数与BSI分级、支扩病程、呼吸症状评分、焦虑量表评分、焦虑等级评定、抑郁量表评分、mMRC、肺CT均显著正相关(P<0.01,P<0.05)。反复加重组中虚实夹杂证有51例[87.93%(51/58)],非反复加重组中虚实夹杂证有1例[1.61%(1/62)]。结论:支气管扩张症患者急性加重次数与临床症状存在明显相关性;而中医证候随着急性加重次数增多呈现由实转虚、虚实夹杂证趋势。Objective:To analyze the clinical characteristics of bronchiectasis patients with acute exacerbations within one year and the correlation with the distribution of traditional Chinese medicine(TCM)syndromes through cross-sectional investigation.Methods:A total of 120 bronchiectasis patients were selected from the outpatient and ward department of pulmonary disease of Xiyuan Hospital,China Academy of Chinese Medical Sciences from April 2021 to March 2022.The number of acute exacerbations with one year and the patient’s bronchiectasis severity index(BSI),respiratory symptom score,modified medical research council(mMRC),pulmonary function,course of bronchiectasis,anxiety and depression scale score,sputum culture,lung CT,etc.were analyzed,and divide the patients into two groups for comparison,in order to explore the distribution of TCM syndrome types.Results:Among the 120 bronchiectasis patients,58(48.33%)were frequent exacerbators and 62(51.67%)were infrequent exacerbators.Spearman correlation analysis showed that the number of acute exacerbations in one year was significantly positively correlated with BSI grading,bronchiectasis course,respiratory symptoms score,anxiety scale score,depression scale score,mMRC and lung CT(P<0.01,P<0.05).There was 51 patients[87.93%(51/58)]of excess and deficiency syndromes in frequent exacerbators group,while one patient[1.61%(1/62)]of excess and deficiency syndromes in infrequent exacerbators group.Conclusion:The number of acute exacerbations in patients with bronchiectasis is significantly correlated with their clinical characteristics.With the increase of acute exacerbation times,TCM syndromes show a trend from excess to deficiency,and excess and deficiency syndromes.

关 键 词：支气管扩张症 急性加重 临床特征 中医证型 横断面研究 

分 类 号：R259[医药卫生—中西医结合]