安徽省孕妇血清碘水平及参考值范围的研究  

Study on serum iodine level and reference value range of pregnant women in Anhui Province

作　　者：刘艳平 李卫东 虞晨[2] 许娴[2] 徐署东[2] 田翠翠 LIU Yanping;LI Weidong;YU Chen;XU Xian;XU Shudong;TIAN Cuicui(School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China;不详)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]安徽省疾病预防控制中心

出　　处：《中国地方病防治》2024年第1期5-8,共4页Chinese Journal of Control of Endemic Diseases

摘　　要：目的了解安徽省孕妇血清碘现况,研究不同孕期血清碘水平变化趋势,探究血清碘相关影响因素,建立安徽省甲状腺功能(以下简称“甲功”)正常孕妇血清碘参考范围值。方法选取2021年安徽省6个省级监测点,采集孕早、中、晚期妇女尿样、血样,检测尿碘、血清碘、TSH、FT_(3)、FT_(4)、TPOAb以及TgAb。采用百分位数法建立甲功正常孕妇血清碘95%参考值范围。结果共检测587例孕妇,尿碘中位数为147.00μg/L,处于碘不足水平(<150μg/L);不同孕期尿碘水平差异无统计学意义(H=4.590,P>0.05);高碘饮食对孕妇血清碘水平没有统计学意义(Z=-0.600,P>0.05),但对尿碘浓度呈弱正相关(r=0.124,P<0,05);血清碘中位数为75.47(60.78,93.25)μg/L,甲功正常孕妇血清碘95%医学参考值范围初步定为32.99~129.43μg/L,不同孕期血清碘水平差异有统计学意义(H=26.20,P<0.05),孕早期血清碘中位数显著低于孕中期、孕晚期(Z=-4.652、Z=-3.920,P均<0.05),孕中期血清碘与孕晚期血清碘中位数差异不具有统计学意义(Z=0.906,P>0.05)。孕期妇女血清碘与TSH存在弱正相关(r=0.10,P<0.05),与FT_(3)、FT_(4)存在弱负相关(r=-0.119、-0.117,P均<0.05),与TPOAb、TgAb无相关性(r=-0.043、-0.030,P均>0.05),孕期妇女血清碘与尿碘无相关性(r=0.032,P>0.05)。结论建立了适合安徽省甲功正常孕妇血清碘的参考值范围,为进一步评价孕妇个体碘营养提供了科学依据。Objective To understand the current status of serum iodine in pregnant women in Anhui Province,study the trend of serum iodine level in different pregnancies,explore the related factors of serum iodine,and establish the reference range of serum iodine in pregnant women with normal thyroid function(hereinafter referred to as"Jia Gong").Methods Six provincial monitoring sites in Anhui Province in 2021 were selected to collect urine and blood samples from women in early,middle and late pregnancy.Urinary iodine,serum iodine and thyroid activity index[thyroid hormone(TSH),free triodothyronine(FT_(3)),free thyroxine(FT_(4)),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)] levels were measured.The 95%reference range of serum iodine in pregnant women with normal thyroid function was established by percentile method.Results A total of 587 pregnant women were tested,and the median urinary iodine was 147.00μg/L,which was in the iodine deficiency level(<150μg/L).There was no significant difference in urinary iodine level among different pregnancies(H=4.590,P>0.05).High iodine diet had no effect on serum iodine level(Z=-0.600,P>0.05),but had a weak positive correlation with urinary iodine concentration(r=0.124,P<0,05).The median serum iodine was 75.47(60.78,93.25)μg/L,and the 95%medical reference range of serum iodine in pregnant women with normal thyroid function was initially set at 32.99-129.43μg/L,and the serum iodine level was significantly different in different pregnancies(H=26.20,P<0.05).The median serum iodine in the first trimester was significantly lower than that in the second trimester and the third trimester(Z=-4.652,Z=-3.920,P<0.05),but there was no significant difference between the median serum iodine in the second trimester and the third trimester(Z=0.906,P>0.05).There was a weak positive correlation between serum iodine and TSH in pregnant women(r=0.10,P<0.05).There was a weak negative correlation with FT_(3) and FT_(4)(r=-0.119,-0.117,P<0.05).There was no correlation with TPOAb and T

关 键 词：血清碘 孕妇 甲功 参考值 

分 类 号：R581[医药卫生—内分泌] R714[医药卫生—内科学]