利那洛肽在结肠镜肠道准备中的辅助应用价值—随机对照单盲临床研究  

The auxiliary application value of linaclotide in colonoscopy bowel preparation—a randomized controlled single-blind clinical study

作　　者：年媛媛 孟宪梅[1] 江振宇[1] 张静洁[1] 刘琳[1] 陈洪锁 许智超 张红杨 牛璐 NIAN Yuan-yuan;MENG Xian-mei;JIANG Zhen-yu;ZHANG Jing-jie;LIU lin;CHEN Hong-suo;XU Zhi-chao;ZHANG Hong-yang;NIU Lu(The Second Affiliated Hospital of Baotou Medical College,014000Baotu,Inner Mongolia,China)

机构地区：[1]包头医学院第二附属医院,内蒙古包头014000

出　　处：《临床消化病杂志》2024年第1期47-52,共6页Chinese Journal of Clinical Gastroenterology

基　　金：内蒙古自治区自然科学基金(No:2019LH08042)。

摘　　要：[目的]比较利那洛肽方案、聚乙二醇电解质方案在结肠镜肠道准备中的效果,分析利那洛肽在肠道准备中的辅助应用价值。[方法]对拟行结肠镜检查的患者随机分为利那洛肽组(319例)和对照组(334例)进行肠道准备,利那洛肽组采用利那洛肽290μg+聚乙二醇电解质2L方案,对照组采用聚乙二醇电解质3L分2次服用法。收集患者基本信息、肠道准备中主观感受和不良反应、排便次数和末次大便性状等资料,结肠镜操作医生采用单盲原则对镜下各阶段肠道的清洁度和泡沫程度进行评分。应用SPSS23.0软件对2组各指标进行统计分析。[结果]利那洛肽组第2阶段排便次数显著多于对照组,2组的总排便次数比较差异无统计学意义。利那洛肽组升结肠、横结肠、降结肠的清洁度、及肠道清洁度总评分与对照组比较差异无统计学意义。利那洛肽组恶心、头晕、口干的发生率显著低于对照组。利那洛肽方案各阶段肠道清洁度均与末次大便清澈度呈正相关。[结论]利那洛肽可辅助用于肠道准备,可减少传统肠道准备药物的剂量、减少饮水量、减轻肠道准备不适症状,从而促进肠道准备的舒适化程度。[Objective]To analyze the application value of linaclotide in bowel preparation before colonoscopy.[Methods]Patients undergoing colonoscopy were randomly divided into two groups for bowel preparation:linaclotide group and control group.Linaclotide 290μg+2Lpolyethylene glycolelectrolyte were used for patients of linaclotide group,and 3Lpolyethylene glycolelectrolyte were used for patients of control group.Patients'information,subjective feelings and adverse reactions during bowel preparation,numbers of bowel movements,and last stool characteristics were collected.Cleanliness and foaminess of every segment of the intestine were scored by colonoscopy operators using the single-blind principle.The SPSS23.0software was used for statistical analysis of the indicators in the two groups.[Results]There were 319patients in linaclotide group and 334patients in control group.There was no statistical difference in the total number of defecation between two groups,and the defecation numbers in linaclotide group was significantly higher than that of control group.There were no statistical difference in the cleanliness scores of ascending colon,transverse colon,descending colon,and the total cleanliness of all intestinal segment between two groups.The incidence of nausea,dizziness,and dry mouth was significantly lower in linaclotide group than that in control group.In the linaclotide group,the average daily stool frequency was negatively correlated with the cleanliness of the descending colon and rectum,while the cleanliness of each segment of the intestine was significantly correlated with the cleanliness of the last stool.[Conclusion]There is auxiliary application value of linaclotide in bowel preparation by reducing the dose of bowel preparation drugs,water consumption and the discomfort.Linaclotide can promote the comfort of bowel preparation.

关 键 词：结肠镜术 利那洛肽 聚乙二醇电解质 肠道准备 

分 类 号：R656.9[医药卫生—外科学]