艾司奥美拉唑联合三氟噻吨/美利曲辛改善糜烂性胃炎患者负性心理的临床疗效  

Clinical effect of esomeprazole plus trifluthixene and meldonium improve negative psychology in patients with erosive gastritis

作　　者：徐成龙 程海俐 张彩凤 吴国斌 XU Cheng-long;CHENG Hai-li;ZHANG Cai-feng;WU Guo-bin(Division 2,Department of Gastroenterology,Cangzhou People's Hospital Headquarters,061000Cangzhou,Hebei,China;Department of Gastroenterology,Shijiazhuang People's Hospital,050000Shijiazhuang,Hebei,China)

机构地区：[1]沧州市人民医院本部消化内科二区,河北沧州061000 [2]石家庄市人民医院消化内科,河北石家庄050000

出　　处：《临床消化病杂志》2024年第1期58-61,共4页Chinese Journal of Clinical Gastroenterology

基　　金：河北省2023年度医学科学研究课题计划(No.20231603)。

摘　　要：[目的]评价艾司奥美拉唑与三氟噻吨/美利曲辛合用与单用艾司奥美拉唑治疗伴负性情绪的糜烂性胃炎的疗效。[方法]纳入140例伴负性情绪的糜烂性胃炎患者,均分为观察组(70例)与对照组(70例)。观察组服用艾司奥美拉唑加三氟噻吨/美利曲辛,对照组服用艾司奥美拉唑,疗程均为4周。观察治疗前后临床症状、胃黏膜糜烂、前列腺素E2(PGE2)和丙二醛(MDA)水平、焦虑、抑郁及复发情况。[结果]治疗后观察组临床症状、黏膜糜烂、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分均低于对照组(P<0.05),PGE2高于对照组(P<0.05),MDA低于对照组(P<0.05)。6个月随访(100%随访率),观察组、对照组分别有16例(22.9%)、34例(48.6%)复发,2组复发率比较差异有统计学意义(P<0.05)。[结论]艾司奥美拉唑联合三氟噻吨/美利曲辛治疗可改善患者的临床症状和黏膜糜烂,缓解患者的负性情绪,降低复发率。合方的疗效高于单方。[Objective]The objective of this study was to evaluate the efficacy of esomeprazole combined with trifluthixene/melittrix versus esomeprazole alone in the treatment of erosive gastritis with negative emotions.[Methods]The totals of 140erosive gastritis patients with negative emotions were included in this study.The control group received esomeprazole in 70cases,and the observation group received esomeprazole plus trifluthixol/melitracen in 70cases.The course of treatment was 4weeks.Clinical symptoms,gastric mucosal erosion,prostaglandin E2(PGE2)and malondialdehyde levels,anxiety,depression and recurrence were observed before and after treatment.[Results]After treatment,the clinical symptoms,mucosal erosion,Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)scores of the observation group were lower than those of the control group(P<0.05),PGE2was higher than that of the control group(P<0.05),and malondialdehyde(MDA)was lower than that of the control group(P<0.05).At 6 months follow-up period(100%follow-up rate),16patients(22.9%)and 34patients(48.6%)in the observation group and control group relapsed,respectively(P<0.05).[Conclusion]Esomeprazole combined with trifluthixene/Melitripacin can improve the clinical symptoms and mucosal erosion,relieve the negative mood in erosive gastritis patients,and reduce the recurrence rate.

关 键 词：胃黏膜 黏膜糜烂 前列腺素E2 丙二醛 负性情绪 

分 类 号：R322.4[医药卫生—人体解剖和组织胚胎学]