番红花的化学成分及其药理作用研究进展  

Research progress on chemical components of Crocus sativus and their pharmacological effects

作　　者：郑优优 陈莹 许琦伟 朱炫虹 杨博涵 邱镇 开国银 冯岳 ZHENG Youyou;CHEN Ying;XU Qiwei;ZHU Xuanhong;YANG Bohan;QIU Zhen;KAI Guoyin;FENG Yue(School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学药学院,杭州310053

出　　处：《植物生理学报》2024年第1期20-34,共15页Plant Physiology Journal

基　　金：国家自然科学基金(82104337和82073963);浙江省自然科学基金(LQ20C010004);浙江省农业新品种选育科技重大专项(2021C02074);国家级大学生创新创业训练计划项目(202210344025X和202210344042)。

摘　　要：番红花(Crocus sativus)为鸢尾科番红花属多年生药用植物,其化学成分主要包括萜类、酚酸类、黄酮类、生物碱类与多糖类等。其中,萜类化合物中的西红花苷、西红花酸、苦藏花素及藏红花醛是其主要药效物质。药理学实验证实番红花具有多种药理作用,如抗肿瘤、抗氧化、抗炎症、免疫调节、抗抑郁症及抗糖尿病等。结合国内外相关文献,本文对番红花的化学成分及其药理作用的研究进展进行综述,以期为番红花的深入研究提供参考依据。Crocus sativus is a traditional Chinese medicine belonging to the genus Crocus in the Iridaceae.Its chemical constituents mainly include terpenoids,phenolic acids,flavonoids,alkaloids and polysaccharides.Among them,crocin,crocetin,picrocrocin and safranal in terpenoids are the main pharmacodynamic substances of C.sativus.Pharmacological studies have shown that it exhibits wide pharmacological activities,including anti-tumor,anti-oxidant,anti-inflammation,immune regulation,anti-depression and anti-diabetes.Combined with the relevant literature at home and abroad,the research progress on chemical components and pharmacological effects of C.sativus is reviewed,which provides a reference for the further research of C.sativus.

关 键 词：番红花 化学成分 药理作用 抗肿瘤 抗氧化 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]