昼夜节律紊乱导致自主神经功能失衡的研究进展  

Autonomic nervous dysfunction caused by circadian disruption:research progress

作　　者：沈琦 谭兴[1] 王伟忠[1] SHEN Qi;TAN Xing;WANG Weizhong(Department of Marine Biomedicine and Polar Medicine,Naval Medical Center,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)海军特色医学中心海洋生物医药与极地医学研究室,上海200433

出　　处：《海军军医大学学报》2024年第3期328-332,共5页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(81970354);上海市自然科学基金(22ZR1478400);海军军医大学(第二军医大学)深蓝人才工程(23TPSL0101);海军军医大学(第二军医大学)海军特色医学中心卓优人才项目(21TPQN0801)。

摘　　要：自主神经功能保持平衡对维持机体功能至关重要,昼夜节律系统参与了自主神经系统功能调节。昼夜节律紊乱会引起交感神经活性增加、迷走神经活性降低,进而促进心血管疾病发生和发展。然而,昼夜节律紊乱导致自主神经功能失衡的机制尚未明确。本文以昼夜节律对自主神经功能的影响为出发点,旨在明确昼夜节律紊乱导致自主神经功能失衡的可能机制,并归纳了褪黑素治疗、光线调节、运动疗法、迷走神经刺激等防治措施。Keeping the balance of autonomic nervous system function is essential to maintain the physiologic function of human body,and the circadian rhythm system is involved in the regulation of autonomic nervous system function.Circadian disruption can increase sympathetic nervous activity and decrease vagus nerve activity,thus promoting the development and progression of cardiovascular disease.However,the mechanism of autonomic nervous function imbalance caused by circadian disruption is not clear.Based on the influence of circadian rhythm on autonomic nervous function,this paper aims to clarify the possible mechanism of autonomic nervous function imbalance caused by circadian disruption,and summarizes the prevention and treatment measures such as melatonin treatment,light regulation,exercise therapy,vagus nerve stimulation,etc.

关 键 词：昼夜节律 自主神经功能失衡 交感神经 防治措施 

分 类 号：R338[医药卫生—人体生理学]