临床药师参与中枢神经系统毛霉菌感染治疗的实践及思考  

Practice and experience of clinical pharmacists participating in the treatment of mucormycosis infection in central nervous system

作　　者：庄伟[1] 齐晓涟[1] 高冉[2] 张婧[2] 杨毅恒[3] 褚燕琦[1] 董宪喆 张兰[1] ZHUANG Wei;QI Xiao-lian;GAO Ran;ZHANG Jing;YANG Yi-heng;CHU Yan-qi;DONG Xie-zhe;ZHANG Lan(Department of Pharmacy,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Department of Neurology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]首都医科大学宣武医院药学部,北京100053 [2]首都医科大学宣武医院神经内科,北京100053 [3]北京大学第三医院药剂科,北京100191

出　　处：《临床药物治疗杂志》2024年第1期85-87,共3页Clinical Medication Journal

摘　　要：中枢神经系统毛霉菌感染是一种病情凶险的颅内感染性疾病,病死率达到50%以上。本文介绍了2例中枢神经系统毛霉菌感染危重病例,并从全身治疗药物的选择、局部治疗用药的选择及两性霉素B的用法用量、治疗疗程与序贯治疗、输注过程中的监护、发生不良反应后的对策等方面进行总结与分析,以期为临床用药提供参考。Mucormycosis infection of the central nervous system is a dangerous intracranial infectious disease with a mor⁃tality rate of over 50%.In this paper,two cases of severe Mucormycosis infection in the central nervous system were intro⁃duced.The selection of systemic and local drugs,the usage and dosage of amphotericin B,the course of treatment and sequen⁃tial treatment,the monitoring and the countermeasures after adverse reactions caused by the application of amphotericin B were summarized and analyzed to a provide reference for clinicians and pharmacists.

关 键 词：毛霉菌感染 两性霉素B 临床药师 

分 类 号：R969.3[医药卫生—药理学] R978.5[医药卫生—药学]