伏立康唑联合亚胺培南西司他丁钠致药物热伴白细胞减少一例  

Drug fever with WBC decrease caused by voriconazole combined with imipenem and cilastatin:a case report

作　　者：林丹 廖琳丹 LIN Dan;LIAO Lin-dan(Department of Pharmacy,the First People′s Hospital of Neijiang,Sichuan Neijiang 641000,China)

机构地区：[1]内江市第一人民医院药剂科,四川内江641000

出　　处：《临床药物治疗杂志》2024年第1期88-90,共3页Clinical Medication Journal

摘　　要：本文报道1例颈脊髓损伤伴四肢瘫患者术后出现肺部感染,给予伏立康唑联合亚胺培南西司他丁钠治疗后,出现发热伴白细胞减少,临床药师查阅资料,对患者临床症状与药物关联性进行分析,建议医师停药后,患者体温和白细胞水平恢复正常。本文结合文献资料对该病例发热伴白细胞减少的发生和治疗过程进行梳理,以期为医师和药师对伏立康唑联合亚胺培南西司他丁钠引起发热伴白细胞减少的鉴别、诊断、治疗及药学监护提供参考。This article reported a case of a patient with cervical spinal cord injury and quadriplegia who developed a pul⁃monary infection after surgery.Fever with WBC decrease occurred after voriconazole combined with imipenem and cilastatin was administered.Clinical pharmacists consulted the literature,analyzed the relationship between the clinical symptoms and drugs,and suggested the physician stop the drugs,and then the patient's temperature and leukocytes returned to normal.This article reviewed the occurrence and treatment process of fever with WBC decrease in this case based on literature,to provide reference for physicians and pharmacists in the identification,diagnosis,treatment,and pharmaceutical care of fever with WBC decrease caused by voriconazole combined with imipenem and cilastatin.

关 键 词：伏立康唑 亚胺培南西司他丁钠 药物热 白细胞减少 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]