腹泻型肠易激综合征动物模型评价的研究进展  

Research progress on animal models for the evaluation of diarrhea-predominant irritable bowel syndrome

作　　者：张佳河 祝旺 沈丹婷 杨希玲 刘凤斌[2,3] 侯秋科[3] ZHANG Jiahe;ZHU Wang;SHEN Danting;YANG Xiling;LIU Fengbin;HOU Qiuke(the First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Baiyun Hospital,the First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Spleen and Stomach Disease,the First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一临床医学院,广州510405 [2]广州中医药大学第一附属医院白云医院,广州510405 [3]广州中医药大学第一附属医院脾胃病科,广州510405

出　　处：《中国实验动物学报》2024年第2期238-247,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金项目(81804047,82174303)。

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是常见的功能性肠病之一,其中腹泻型肠易激综合征(diarrhea-predominant IBS,IBS-D)占比最多,发病机制复杂多样,且缺少临床特效药。动物模型的制备是进一步研究疾病机制、评价临床药效以及药物开发的重要基础,而模型制备和评价标准关乎研究的质量。本文通过查阅国内外文献及结合本课题组的前期建模经验,基于IBS-D目前公认的发病机制出发,从腹泻情况观察,内脏敏感性测定,肠道动力测定等方面系统总结IBS-D动物模型的评价方法,以期为今后研究提供参考。Irritable bowel syndrome(IBS)is one of the most common functional gastrointestinal disorders,of which diarrhea-predominant IBS(IBS-D)accounts for the largest proportion.The pathogenesis of IBS-D is complicated and diverse,and there is currently a lack of clinically effective drugs.The establishment of animal models is an essential tool for further studies of the disease mechanisms,evaluation of clinical efficacy,and drug development,and the preparation and evaluation standards of models are important factors affecting the quality of the research.Based on the currently accepted pathogenesis of IBS-D and the previous modeling experience of our research group,this review systematically summarizes the evaluation method used in animal models of IBS-D in terms of diarrhea observation,visceral sensitivity tests,and intestinal motility tests,to provide a reference for future studies.

关 键 词：腹泻型肠易激综合征(IBS-D) 动物模型 评价方式 

分 类 号：Q95-33[生物学—动物学]