卵巢储备功能减退动物模型研究进展  

Research progress on animal models of diminished ovarian reserve

作　　者：何瑞芬 杨永秀[2] 梁晓磊[2] HE Ruifen;YANG Yongxiu;LIANG Xiaolei(the First Clinical Medical College of Lanzhou University,Lanzhou 730000,China,China;Department of Obstetrics and Gynecology,Key Laboratory for Gynecologic Oncology Gansu Province,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院妇产科,甘肃省妇科肿瘤重点实验室,兰州730000

出　　处：《中国实验动物学报》2024年第2期254-259,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金项目(81960278)。

摘　　要：卵巢储备功能减退(diminished ovarian reserve,DOR)由于女性卵巢内剩余的卵母细胞数量和/或质量下降,导致卵巢功能减退,是卵巢功能下降的早期阶段,包括与高龄相关的生理性DOR和病理因素导致的病理性DOR。DOR可进展为早发性卵巢功能不全、卵巢早衰,对女性健康产生深远影响,而目前仍无有效方法逆转卵巢功能衰退。人类卵巢资源的有限性和医学伦理的要求,使得必须通过建立合适的动物模型去探究卵巢功能衰退的分子机制,寻找其预测及治疗靶点。本文总结目前常用的DOR啮齿类动物造模方法,为相关基础研究提供参考。Diminished ovarian reserve(DOR)is associated with a reduced quantity and/or quality of retrieved oocytes,usually leading to low numbers of retrieved oocytes and poor reproductive outcomes.DOR may potentially progress to premature ovarian insufficiency and premature ovarian failure,which have adverse impacts on women’s health.There is currently no effective clinical treatment to rescue ovarian function.The limited availability of human ovarian tissues and medical ethics issues mean that animal models are crucial for improving our understanding of the molecular pathogenesis of DOR and identifying preventive and therapeutic targets.This review thus aims to summarize the techniques and strategies used to establish rodent models of DOR,to provide a reference for future studies.

关 键 词：卵巢储备 动物模型 啮齿类动物 

分 类 号：Q95-33[生物学—动物学]