糖化血红蛋白、同型半胱氨酸与中老年急性冠脉综合征患者冠脉病变相关性分析  

Correlation between glycosylated hemoglobin,homocysteine and coronary artery lesions in middle-aged and elderly patients with acute coronary syndrome

作　　者：欧宇筹 李明琰[1] 黎锦辉 谢宇洲 陈梓伟 何文凯[1] OU Yu-chou;LI Ming-yan;LI Jin-hui;XIE Yu-zhou;CHEN Zi-wei;HE Wen-kai(Department of Cardiovasology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,China)

机构地区：[1]广州医科大学附属第二医院心血管内科,广东广州510000

出　　处：《广东医科大学学报》2024年第1期61-64,共4页Journal of Guangdong Medical University

摘　　要：目的 了解糖化血红蛋白(HbA1c)、同型半胱氨酸(Hcy)与急性冠脉综合征(ACS)患者冠脉病变相关性。方法 515例中老年ACS患者根据冠脉造影结果分为单支冠脉病变组和多支冠脉病变组,根据Gensini评分分为轻度和中重度病变组,采用Pearson相关性分析HbA1c、Hcy与冠脉病变相关性。结果 单支、轻度病变组HbA1c、Hcy水平低于多支、中重度病变组(P<0.01或0.05)。HbA1c水平与多支病变存在正相关(r=0.103,P<0.05),而Hcy水平与病变严重程度存在正相关(r=0.164,P<0.01)。结论 高水平HbA1c、Hcy分别与中老年ACS患者冠脉多支、中重度冠脉病变发生有关。Objective To investigate the correlation between glycosylated hemoglobin(HbA1c),homocysteine(Hcy)and coronary artery lesions in middle-aged and elderly patients with acute coronary syndrome(ACS).Methods A total of 515 middle-aged and elderly patients with ACS were divided into single-vessel and multi-vessel groups according to coronary angiography,and mild and moderate/severe groups based on Gensini scores.The correlation between HbA1c,Hcy and coronary artery lesions was evaluated by Pearson correlation analysis.Results HbA1c and Hcy levels were lower in single-vessel and mild ACS groups than in multi-vessel and moderate/severe ACS groups(P<0.01 or 0.05).There were positive correlations between HbA1c and multi-vessel lesions(r=0.103,P<0.05)and between Hcy and moderate/severe ACS(r=0.164,P<0.01).Conclusion HbA1c and Hcy could be respectively contribute to multi-vessel lesions and moderate/severe ACS in middle-aged and elderly patients.

关 键 词：糖化血红蛋白 同型半胱氨酸 急性冠脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]