抗生素序贯疗法治疗小儿支气管肺炎的临床效果  

Clinical effect of sequential antibiotic therapy in the treatment of bronchopneumonia in children

作　　者：王映珍 WANG Yingzhen(Department of Pediatrics,the First People’s Hospital of Longxi County,Gansu Province,Longxi 748100,C hina)

机构地区：[1]甘肃省陇西县第一人民医院儿科,甘肃陇西748100

出　　处：《妇儿健康导刊》2024年第5期21-24,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨抗生素序贯疗法治疗小儿支气管肺炎的临床效果。方法选取2021年8月至2022年10月陇西县第一人民医院收治的113例支气管肺炎患儿作为研究对象,按照随机数字表法分为对照组(56例)与试验组(57例)。对照组采用常规治疗方法,试验组采用抗生素序贯疗法。比较两组治疗效果、白细胞计数、C反应蛋白水平、临床症状消失时间、不良反应总发生率及炎症因子水平。结果试验组总有效率高于对照组(P<0.05)。治疗后,试验组白细胞计数、C反应蛋白水平均低于对照组(P<0.05)。试验组各项临床症状消失时间均短于对照组(P<0.05)。试验组不良反应总发生率低于对照组(P<0.05)。试验组γ干扰素、肿瘤坏死因子-α及白细胞介素-6水平均低于对照组(P<0.05)。结论抗生素序贯疗法治疗小儿支气管肺炎的临床效果确切,可加速临床症状的改善,降低白细胞计数、C反应蛋白及炎症因子水平,且具有安全性,值得临床推广。Objective To investigate the clinical effect of sequential antibiotic therapy in the treatment of bronchopneumonia in children.Methods A total of 113 children with bronchopneumonia admitted to the First People’s Hospital of Longxi County from August 2021 to October 2022 were selected as the study objects and divided into the control group(56 cases)and the experimental group(57 cases)according to the random number table method.The control group received conventional treatment,and the experimental group received sequential antibiotic therapy.The therapeutic effect,white blood cell count,C-reactive protein level,clinical symptom disappearance time,total incidence of adverse reactions and inflammatory factor levels were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,white blood cell count and C-reactive protein level in the experimental group were lower than those in the control group(P<0.05).The disappearance time of clinical symptoms in the experimental group was shorter than that in the control group(P<0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group(P<0.05).The levels of interferon-γ,tumor necrosis factor-αand interleukin-6 in the experimental groups were lower than those in the control group(P<0.05).Conclusion The clinical effect of sequential antibiotic therapy in the treatment of bronchopneumonia in children is precise,it can accelerate the improvement of clinical symptoms,reduce the levels of white blood cell count,C-reactive protein and inflam matory factors,and it is safe and worthy of clinical promotion.

关 键 词：抗生素序贯疗法 小儿支气管肺炎 白细胞计数 C反应蛋白 

分 类 号：R725.6[医药卫生—儿科]