25-羟维生素D水平与产后抑郁的相关性分析及其对不良妊娠结局的预测价值  

Correlation analysis of 25-hydroxyvitamin D level with postpartum depression and its predictive value for adverse pregnancy outcome

作　　者：王兰玲[1] 王执勇[2] WANG Lanling;WANG Zhiyong(Department of Obstetrics,Weifang Maternal and Child Health Hospital,Shandong Province,Weifang 261011,China;Department of Pediatrics,Weifang Maternal and Child Health Hospital,Shandong Province,Weifang 261011,China)

机构地区：[1]山东省潍坊市妇幼保健院产科,山东潍坊261011 [2]山东省潍坊市妇幼保健院儿科,山东潍坊261011

出　　处：《妇儿健康导刊》2024年第5期196-198,F0003,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：山东省医药卫生科技发展计划项目(2018W S093)。

摘　　要：目的分析25-羟维生素D[25(OH)D]水平与产后抑郁的相关性及其对不良妊娠结局的预测价值。方法选择2021年1月至2023年1月于潍坊市妇幼保健院进行孕检的115例妊娠晚期(28~40周)孕妇,根据孕妇血清25(OH)D水平分为缺乏组(n=37,<50nmol/L)、不足组(n=46,50~75nmol/L)、正常组(n=32,>75nmol/L),比较不同25(OH)D水平孕妇产后抑郁程度(EPDS)、不良妊娠结局发生情况,分析25(OH)D水平与EPDS不良妊娠结局的相关性,并采用受试者工作特征(ROC)曲线分析25(OH)D对不良妊娠结局的预测价值。结果三组EPDS评分比较,差异有统计学意义(P<0.001);25(OH)D水平与EPDS评分呈负相关性(P<0.05);ROC曲线分析结果显示,25(OH)D预测不良妊娠结局的曲线下面积为0.855,敏感度为0.875,特异度为0.768。结论妊娠晚期孕妇血清25(OH)D水平与产后抑郁具有相关性,缺乏25(OH)D会增加产后抑郁发生的可能性,且25(OH)D可以预测不良妊娠结局,建议临床重视并加强对孕妇维生素D的监测及补充。Objective To analyze the correlation of 25-hydroxyvitamin D[25(OH)D]level with postpartum depression and its predictive value for adverse pregnancy outcome.Methods A total of 115 pregnant women in the third trimester of pregnancy(28-40 weeks)who underwent pregnancy examination in Weifang Maternal and Child Health Hospital from January 2021 to January 2023 were selected.According to the serum 25(OH)D level of pregnant women,they were divided into deficiency group(n=37,<50 nmol/L),insufficiency group(n=46,50-75 nmol/L),normal group(n=32,>75 nmol/L).The degree of postpartum depression(EPDS)and adverse pregnancy outcomes of pregnant women with different 25(OH)D levels were compared,and the correlation between 25(OH)D levels and EPDS and adverse pregnancy outcomes was analyzed.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of 25(OH)D for adverse pregnancy outcomes.Results There was statistically significant difference in EPDS score among the three groups(P<0.001).Serum 25(OH)D level was negatively correlated with EPDS score(P<0.05).ROC curve analysis showed that the area under the curve of 25(OH)D for predicting adverse pregnancy outcomes was 0.855,the sensitivity was 0.875,and the specificity was 0.768.Conclusion The serum 25(OH)D level of pregnant women in the third trimester is correlated with postpartum depression,lack of 25(OH)D will increase the possibility of postpartum depression,and 25(OH)D can predict adverse pregnancy outcomes,so it is recommended to pay attention to and strengthen the monitoring and supplement of vitamin D in pregnant women.

关 键 词：25-羟维生素D 孕妇 产后抑郁 不良妊娠结局 

分 类 号：R714[医药卫生—妇产科学]