抗结核固定剂量复合剂对初治活动性肺结核患者病灶吸收效果的影响  

Effect of Anti-tuberculosis Fixed-dose Compound on the Effect of Lesion Absorption in Patients with First-treatment Active Pulmonary Tuberculosis

作　　者：黄玲[1] 谢文芳 赵玉杭[1] HUANG Ling;XIE Wenfang;ZHAO Yuhang(Department of Tuberculosis Prevention and Control,Fuzhou Center for Disease Control and Prevention,Fuzhou,Fujian Province,350001 China;Fuzhou Tuberculosis Prevention and Control Hospital,Fuzhou,Fujian Province,350001 China)

机构地区：[1]福州市疾病预防控制中心结核病防治科,福建福州350001 [2]福州结核病防治院,福建福州350001

出　　处：《中外医疗》2024年第1期98-101,共4页China & Foreign Medical Treatment

摘　　要：目的探讨抗结核固定剂量复合剂对初治活动性肺结核患者病灶吸收效果的影响。方法便利选取2021年2月—2023年1月福州结核病防治院收治的初治活动性肺结核患者64例为研究对象,按照随机数表法分为两组。对照组(32例)给予常规抗结核药物治疗,观察组(32例)实施抗结核固定剂量复合剂治疗。对比两组治疗总有效率、痰菌阴转率、病灶吸收情况、不良反应。结果观察组总有效率为93.75%,高于对照组的75.00%,差异有统计学意义(χ^(2)=4.267,P<0.05)。观察组第2、5、6个月的痰菌阴转率均高于对照组,差异有统计学意义(P均<0.05)。治疗第2、6个月,两组患者病灶吸收情况相比,差异无统计学意义(P>0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论在初治活动性肺结核患者中应用抗结核固定剂量复合剂治疗效果显著,能够增强病灶吸收率,提高痰菌阴转率。Objective To investigate the effect of anti-tuberculosis fixed-dose compound on the effect of lesion resorption in patients with first-treatment active pulmonary tuberculosis.Methods 64 patients with first-treatment active pulmonary tuberculosis admitted to Fuzhou Tuberculosis Prevention and Control Hospital from February 2021 to January 2023 were conveniently selected as the study subjects and divided into two groups according to the method of randomized numerical table.The control group(32 cases)was given conventional anti-tuberculosis drug treatment,and the observation group(32 cases)were treated with anti-tuberculosis fixed-dose compound.The total effective rate,sputum negative rate,lesion absorption,and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 93.75%,which was higher than that of the control group 75.00%,the difference was statistically significant(χ^(2)=4.267,P<0.05).The sputum negative conversion rate in the observation group were higher than those in the control group at the 2nd,5th and 6th months,and the differences were statistically significant(all P<0.05).At the 2nd and 6th month of treatment,there was no significant difference in lesion absorption between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of anti-tuberculosis fixed-dose compound therapy in patients with first-treatment active pulmonary tuberculosis is effective,which can enhance the rate of lesion absorption and improve the sputum negative rate.

关 键 词：初治活动性肺结核 抗结核固定剂量复合剂 病灶吸收效果 痰菌阴转率 不良反应 病灶缩小 

分 类 号：R521[医药卫生—内科学]