低分子肝素钙应用于过敏性紫癜患儿肾损害治疗中的临床效果分析  

Clinical Effect Analysis of Low Molecular Weight Heparin Calcium Application in the Treatment of Renal Impairment in Children with Henoch-Schoenlein Purpura

作　　者：陈茵治 王诗红 许晓东 CHEN Yinzhi;WANG Shihong;XU Xiaodong(Department of Pediatrics,Nan'an Hospital,Nan'an,Fujian Province,362300 China)

机构地区：[1]南安市医院儿科,福建南安362300

出　　处：《中外医疗》2024年第2期89-92,共4页China & Foreign Medical Treatment

摘　　要：目的研究分析予以过敏性紫癜患儿低分子肝素钙对其肾损害治疗作用及临床应用价值。方法方便选取2021年7月—2022年7月于南安市医院儿科就诊的74例患有过敏性紫癜患儿作为研究对象,根据奇偶数方式分为常规组与观察组,每组37例。常规组做常规治疗,观察组行常规治疗+低分子肝素钙。比较两组肾功能、证候积分、肾损害发生率。结果治疗前两组肾功能比较,差异无统计学意义(P>0.05);治疗后观察组肾功能改善优于常规组,差异有统计学意义(P<0.05)。治疗前两组症候积分比较,差异无统计学意义(P>0.05);治疗后观察组症候积分低于常规组,差异有统计学意义(P<0.05)。观察组肾损害发生率为5.40%,低于常规组的21.62%,差异有统计学意义(χ^(2)=4.163,P<0.05)。结论过敏性紫癜患儿行疾病治疗中,低分子肝素钙的应用有助于降低患儿肾损害发生率,维护肾功能。Objective To study and analyze the therapeutic effect of low molecular weight heparin calcium on the treatment of renal impairment in children with Henoch-Schoenlein purpura and the value of clinical application.Methods A total of 74 children with anaphylactoid purpura who were treated in the Department of Pediatrics of Nan'an Hospital from July 2021 to July 2022 were conveniently selected as the study objects,and were divided into routine group and observation group according to odd-even mode,with 37 cases in each group.The conventional group received conventional treatment,and the observation group received conventional treatment+low molecular weight heparin calcium.Renal function,syndrome score and incidence of renal damage were compared between the two groups.Results There was no statistically significant difference in renal function between the two groups before treatment(P>0.05).After treatment,the improvement of renal function in observation group was better than that in conventional group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups before treatment(P>0.05).After treatment,the symptom score of observation group was lower than that of conventional group,and the difference was statistically significant(P<0.05).The incidence of renal damage in the observation group was 5.40%,which was lower than 21.62%in the conventional group,and the difference was statistically significant(χ^(2)=4.163,P<0.05).Conclusion In the treatment of children with henoch purpura,the application of low molecular weight heparin calcium is helpful to reduce the incidence of kidney damage and maintain renal function.

关 键 词：低分子肝素钙 过敏性紫癜 肾损害 临床效果 

分 类 号：R5[医药卫生—内科学]