沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘合并肺部感染的临床效果  

Clinical effect of salbutamol combined with budesonide nebulized inhalation in the treatment of bronchial asthma complicated by pulmonary infection

作　　者：李红妹 LI Hongmei(Geriatrics,Red Cross Hospital of Yulin City,Guangxi Zhuang Autonomous Region,Yulin 537000,China)

机构地区：[1]广西壮族自治区玉林市红十字会医院老年病科,537000

出　　处：《临床合理用药杂志》2024年第8期25-28,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘合并肺部感染的临床效果。方法选取2019年1月—2022年6月玉林市红十字会医院收治的支气管哮喘合并肺部感染患者136例,采用随机数字表法分为观察组和对照组,各68例。在常规治疗基础上,对照组予吸入用布地奈德混悬液治疗,观察组在对照组基础上加吸入用硫酸沙丁胺醇溶液治疗,2组均持续治疗2周。比较2组患者的临床疗效、临床表现(呼吸困难、咳嗽、喘息、气急及哮鸣音)持续时间、治疗前后气道重塑指标[转化生长因子-β(TGF-β)、基质金属蛋白酶因子-9(MMP-9)、基质金属蛋白酶抑制因子-1(TIMP-1)]、治疗前后肺功能指标[用力肺活量(FVC)、呼气流量峰值(PEF)、第1秒用力呼气容积(FEV 1)]及不良反应。结果观察组患者治疗总有效率为98.53%,高于对照组的82.35%(χ2=10.291,P=0.001);观察组患者呼吸困难、咳嗽、喘息、气急以及哮鸣音等表现持续时间均短于对照组(P均<0.01);治疗后,2组血清TGF-β、MMP-9、TIMP-1水平均较治疗前降低,FVC、PEF、FEV 1均较治疗前增加,且观察组变化大于对照组(P均<0.01);观察组患者未出现不良反应,对照组患者中出现轻度头痛1例(1.47%),2组比较差异无统计学意义(P=1.000)。结论沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘合并肺部感染的临床效果肯定,可促进患者气道重塑和肺功能恢复,且安全性高。Objective To observe the clinical effects of salbutamol combined with budesonide nebulized inhalation in the treatment of bronchial asthma complicated with pulmonary infection.Methods One hundred and thirty-six cases of patients with bronchial asthma and concomitant lung infection admitted to Red Cross Hospital of Yulin City from January 2019 to June 2022 were selected.Using the random number table method,they were divided into an observation group and a control group,with 68 cases each.In addition to conventional treatment,the control group received budesonide suspension for inhalation,while the observation group received salbutamol sulfate inhalation solution in addition to the treatment given to the control group.Both groups received continuous treatment for 2 weeks.The clinical efficacy of the two groups,the duration of clinical symptoms(including difficulty breathing,cough,wheezing,shortness of breath,and wheezing sounds),changes in airway remodeling indicators(TGF-β,MMP-9,TIMP-1)and pulmonary function indicators(FVC,PEF,FEV 1)before and after treatment,as well as adverse reactions,were compared.Results The overall effective rate of treatment in the observation group was 98.53%,which was higher than the control group′s 82.35%(χ2=10.291,P=0.001).The duration of symptoms such as difficulty breathing,cough,wheezing,shortness of breath,and wheezing sounds in the observation group was shorter than that in the control group(P<0.01 for all).After treatment,the serum levels of TGF-β,MMP-9,and TIMP-1 decreased,while FVC,PEF,and FEV 1 increased in both groups,with greater changes observed in the observation group compared to the control group(P<0.01 for all).No adverse reactions were observed in the observation group,while one case of mild headache was reported in the control group(1.47%),but the difference between the two groups was not statistically significant(P=1.000).Conclusion The clinical effectiveness of combined salbutamol and budesonide nebulized inhalation therapy for bronchial asthma with concomitant

关 键 词：支气管哮喘 肺部感染 布地奈德 沙丁胺醇 雾化吸入 治疗效果 安全性 

分 类 号：R562.25[医药卫生—呼吸系统] R563.1[医药卫生—内科学]