血清脑钠肽、降钙素原变化与心衰患者NYHA分级的相关性研究  

Correlation Study of Serum Brain Natriuretic Peptide and Procalcitonin Changes with NYHA Classification in Heart Failure Patients

作　　者：王文静 王文青 刘明丽 WANG Wenjing;WANG Wenqing;LIU Mingli(Department of Geriatrics,Yuxi Second People′s Hospital,Yuxi,Yunnan Province,653100 China;Operating room,Honghezhou Hospital of Traditional Chinese Medicine,Honghe,Yunnan Province,654300 China;Laboratory Department,Yuxi Second People′s Hospital,Yuxi,Yunnan Province,653100 China)

机构地区：[1]玉溪市第二人民医院老年病科,云南玉溪653100 [2]云南省红河州中医院手术室,云南红河654300 [3]玉溪市第二人民医院检验科,云南玉溪653100

出　　处：《系统医学》2024年第1期75-78,共4页Systems Medicine

摘　　要：目的分析血清脑钠肽、降钙素原变化与心力衰竭患者纽约心脏病协会(New York Heart Association,NYHA)分级的相关性。方法选取2019年5月—2023年2月云南省玉溪市第二人民医院收治的97例心力衰竭患者为研究对象,所有患者都进行NYHA心功能分级后分为3组,心功能Ⅱ级57例(Ⅱ级组),心功能Ⅲ级28例(Ⅲ级组),心功能Ⅳ级12例(Ⅳ级组),检测3组血清脑钠肽、降钙素原含量并进行相关性分析。结果随着NYHA分级的增加,患者的左室射血分数明显降低,左室舒张末期内径明显升高,差异有统计学意义(P均<0.05)。随着NYHA分级的增加,患者的血清脑钠肽、降钙素原含量明显升高,差异有统计学意义(P均<0.05)。Spearman分析显示NYHA分级与血清脑钠肽、降钙素原含量、左室射血分数、左室舒张末期内径存在相关性(r=0.714、0.746、-0.788、0.692,P均<0.05)。结论心力衰竭患者多伴随有血清脑钠肽、降钙素原的高表达,与患者的NYHA分级存在相关性,可作为判断患者病情的重要依据。Objective To analyze the correlation between the changes of serum brain natriuretic peptide and procalcitonin and the New York Heart Association(NYHA)classification of heart failure patients.Methods A total of 97 patients with heart failure who were admitted to the Yuxi Second People′s Hospital,Yunnan Province from May 2019 to February 2023 were selected as the research objects.All patients were divided into 3 groups after NYHA cardiac function classification,including 57 cases of cardiac function gradeⅡ(classⅡgroup),28 cases of cardiac function gradeⅢ(classⅢgroup),12 cases of cardiac function gradeⅣ(classⅣgroup).The serum levels of brain natriuretic peptide and procalcitonin of three groups were detected and the correlation was analyzed.Results With the increase of NYHA classification,left ventricular ejection fraction was significantly decreased,and left ventricular end-diastolic diameter was significantly increased,and the differences were statistically significant(both P<0.05).With the increase of NYHA classification,the serum levels of brain natriuretic peptide and procalcitonin were significantly increased,and the differences were statistically significant(both P<0.05).Spearman analysis showed that NYHA classification was correlated with serum brain natriuretic peptide,procalcitonin,left ventricular ejection fraction and left ventricular end-diastolic diameter(r=0.714,0.746,-0.788,0.692,all P<0.05).Conclusion Heart failure patients are mostly accompanied by high expression of serum brain natriuretic peptide and procalcitonin,and there is a correlation with patients′NYHA classification,which can be used as an important basis for judging patients′conditions.

关 键 词：心力衰竭 脑钠肽 降钙素原 纽约心脏病协会心功能分级 相关性 左室舒张末期内径 

分 类 号：R544[医药卫生—心血管疾病]