血清细胞因子在儿童肺炎支原体肺炎发病机制中的作用  

Role of Serum Cytokines in the Pathogenesis of Mycoplasma Pneumoniae Pneumonia in Children

作　　者：胡剑[1] 苏凡 包丽丽 吴萍[1] HU Jian;SU Fan;BAO Lili;WU Ping(Department of Pediatrics,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou,Jiangsu Province,215002 China)

机构地区：[1]南京医科大学附属苏州医院儿科,江苏苏州215002

出　　处：《系统医学》2024年第1期145-148,共4页Systems Medicine

摘　　要：目的探索细胞因子在儿童难治性肺炎支原体肺炎致病机制中的作用。方法回顾性选取2019年7月—2020年6月在南京医科大学附属苏州医院儿科住院的203例肺炎支原体肺炎患儿的临床资料,分为难治性肺炎支原体肺炎(Refractory Mycoplasma Pneumoniae Pneumonia,RMPP)组(n=26)和非RMPP组(n=177)。通过倾向评分匹配分析方法配对出25对患儿,校正混杂因素包括性别、年龄、发热、喘息、白细胞及中性粒细胞计数、影像学等特征(大叶性/支气管肺炎、胸腔积液、肺不张)。比较两组患儿血清细胞因子[血清白介素-2(Interleukin-2,IL-2)、白介素-4(Interleukin-4,IL-4)、白介素-6(Interleukin-6,IL-6)、白介素-10(Interleukin-10,IL-10)、肿瘤坏死因子α(Tumor Necrosis Factor-α,TNF-α)和干扰素-γ(Interferon-γ,IFN-γ)]。结果RMPP组的IL-6[18.220(7.088,40.412)pg/mL]、IL-10[7.335(4.838,11.690)pg/mL]、INF-γ[6.450(3.488,15.488)pg/mL]显著高于非RMPP组,差异有统计学意义(Z=1426.000、1176.000、1438.000,P均<0.05)。匹配后RMPP组IL-10[7.840(4.755,11.690)pg/mL]仍显著高于非RMPP组,差异有统计学意义(Z=173.500,P<0.05)。结论本研究结果显示RMPP组的IL-10显著上升,提示IL-10可能在RMPP的发病机制中起作用。Objective To explore the role of cytokines in the pathogenesis of refractory Mycoplasma pneumoniae pneumonia in children.Methods The chinical datae 203 children with Mycoplasma pneumoniae pneumonia who were hospitalized in the Department of Pediatrics of Suzhou Hospital affiliated to Nanjing Medical University from July 2019 to June 2020 were retrospectively selected and divided into refractory Mycoplasma pneumoniae pneumonia(RMPP)group(n=26)and non-RMPP group(n=177).25 pairs of children were matched by propensity score matching analysis,correcting for confounders including gender,age,fever,wheezing,white blood cell and neutrophil counts,imaging and other characteristics(lobar/bronchopneumonia,pleural effusion,lung atelectasis).Compared serum cytokines[Serum interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ)]in two groups of children.Results IL-6[18.220(7.088,40.412)pg/mL],IL-10[7.335(4.838,11.690)pg/mL],and INF-γ[6.450(3.488,15.488)pg/mL]in the RMPP group were significantly higher than those in the non-RMPP group,and the differences were statistically significant(Z=1426.000,1176.000,1438.000,all P<0.05).IL-10[7.840(4.755,11.690)pg/mL]in the matched RMPP group remained significantly higher than that in the non-RMPP group,and the difference was statistically significant(Z=173.500,P<0.05).Conclusion The results of this study showed a significant increase in IL-10 in the RMPP group,suggesting that IL-10 may play a role in the pathogenesis of RMPP.

关 键 词：难治性肺炎支原体肺炎 白介素-10 白介素-6 干扰素-Γ 儿童 

分 类 号：R544[医药卫生—心血管疾病]