NLRP3炎症小体在心力衰竭中的作用及相关治疗的研究进展  

Role of NLRP3 Inflammasome in Heart Failure and Related Therapy

作　　者：夏茂银 刘思泰 贾冬霞[2] 李静 梁财 王国春 XIA Maoyin;LIU Sitai;JIA Dongxia;LI Jing;LIANG Cai;WANG Guochun(Department of Clinical Medicine,Sichuan North Medical College,Nanchong 637000,Sichuan,China;Sichuan Mianyang 404 Hospital,Mianyang 621000,Sichuan,China)

机构地区：[1]川北医学院临床医学系,四川南充637000 [2]四川绵阳四○四医院,四川绵阳621000

出　　处：《心血管病学进展》2024年第2期130-135,共6页Advances in Cardiovascular Diseases

基　　金：四川医院管理和发展研究中心2022年度科研项目(SCYG2022-63);绵阳市卫健委2022年科研课题(202215)。

摘　　要：心力衰竭是许多心血管疾病的终末阶段,由于人口老龄化、心力衰竭合并症和危险因素负担加重,患病率不断增加。几十年来虽然在其诊疗方面有了巨大的进展,但目前仍缺乏具体且有效的治疗方案。NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎症小体是一种蛋白质复合物,可参与心室重塑病理生理过程,进而影响心力衰竭的发生和进展。抑制NLRP3炎症小体激活是减少心力衰竭不良心室重塑和改善左心室功能的可行策略。现就NLRP3炎症小体的结构功能、激活途径、在心力衰竭中的作用及相关治疗进行综述。Heart failure is the end stage of many cardiovascular diseases and its prevalence is increasing due to the aging population and the increased burden of heart failure comorbidities and risk factors.Despite tremendous advances in its diagnosis and treatment over the decades,specific and effective therapeutic options are still lacking.NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome is a protein complex that can participate in the pathophysiological process of ventricular remodeling,which in turn affects the onset and progression of heart failure.Inhibition of NLRP3 inflammasome activation is a feasible strategy to reduce adverse ventricular remodeling and improve left ventricular function in heart failure.The structural functions,activation pathways,roles in heart failure,and related therapies of NLRP3 inflammasome are reviewed.

关 键 词：心力衰竭 心室重塑 NOD样受体热蛋白结构域相关蛋白3炎症小体 炎症 

分 类 号：R541.6[医药卫生—心血管疾病]