脂肪酸代谢紊乱与糖尿病血管微循环障碍  

Fatty Acid Metabolism Disorders and Diabetic Vascular Microcirculation Dysfunction

作　　者：宇文雅 王西强 刘静[2,3] 刘仲伟 YUWEN Ya;WANG Xiqiang;LIU Jing;LIU Zhongwei(School of Medicine,Xizang Minzu University,Xianyang 712082,Shaanxi,China;Department of Cardiology,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi,China;Integretive Traditional Chinese Medicine and Western Medicien Key Lab,Research Office of Shaanxi Administration of Traditional Chinses Medicine,Xi’an 710068,Shaanxi,China)

机构地区：[1]西藏民族大学医学院,陕西咸阳712082 [2]陕西省人民医院心血管内科,陕西西安710068 [3]陕西省中医药管理局中西医结合重点研究室,陕西西安710068

出　　处：《心血管病学进展》2024年第2期168-173,共6页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(82070858)。

摘　　要：脂肪酸过氧化物、脂质过氧化产物以及饱和脂肪酸是糖尿病脂肪酸代谢紊乱的特征性病理代谢产物,可通过诱导血小板聚集、引发血管收缩、增加血管通透性、诱发炎症反应等一系列机制,导致构成微循环结构的重要细胞发生功能障碍和损伤,诱发微循环障碍。现对上述机制及相关新型治疗策略做一综述,为其临床防治提供新的线索与思路。Fatty acid peroxidation products,lipid peroxidation products,and saturated fatty acids are characteristic pathological metabolic products of fatty acid metabolic disorder in diabetes.They can induce platelet aggregation,trigger vasoconstriction,increased vascular permeability,and provoke inflammatory responses.These mechanisms lead to dysfunction and damage of vital cells that constitute the microcirculation,thus inducing microcirculatory disorders.This review discusses the above mechanisms and related novel therapeutic strategies,providing new clues and ideas for their clinical prevention and treatment.

关 键 词：糖尿病 脂肪酸代谢 微循环障碍 

分 类 号：R587.1[医药卫生—内分泌]