HIV合并结核与单纯HIV感染患者焦虑抑郁症状网络特征的比较研究  

A comparative study of the network characteristics of anxiety and depression symptoms between HIV patients co-infected with tuberculosis and sole HIV infection patients

作　　者：邓秋霞 余骏雯 叶丽丽 朱政[2,3,4] 张丽媛 何婷[1] 和继莲 王辉 刘晓宁[1] DENG Qiuxia;YU Junwen;YE Lili;ZHU Zheng;ZHANG Liyuan;HE Ting;HE Jilian;WANG Hui;LIU Xiaoning(Shenzhen Third People's Hospital,Shenzhen 518112,Guangdong,China;School of Nursing,Fudan University,Shanghai 200032,China;Shanghai Evidence-Based Nursing Centre,Shanghai 200032,China;NYU Rory Meyers College of Nursing,New York University,New York City 10010,United States)

机构地区：[1]深圳市第三人民医院,广东深圳518112 [2]复旦大学护理学院,上海200032 [3]上海市循证护理中心,上海200032 [4]纽约大学护理学院,美国纽约10010

出　　处：《护士进修杂志》2024年第6期561-570,共10页Journal of Nurses Training

基　　金：广东省深圳市科技创新委员会基础研究(面上)项目(编号:JCYJ2021032413605015)。

摘　　要：目的探索并比较人类免疫缺陷病毒(HIV)合并结核与单纯HIV感染患者焦虑抑郁症状网络特征。方法对2018年1月-2023年6月在深圳市第三人民医院住院治疗的HIV合并结核与单纯HIV感染患者进行横断面调查。收集患者一般资料、疾病相关资料、焦虑抑郁情绪资料,将纳入对象分为HIV合并结核与单纯HIV感染组进行倾向性评分匹配后纳入网络分析。使用qgraph包可视化网络,网络布局采用Fruchterman-Reingold算法生成,比较2组人群焦虑抑郁症状网络特征间的差异。结果经过倾向性评分匹配后共520例患者数据纳入网络分析,每组260例患者。发现HIV合并结核与单纯HIV感染患者的焦虑症状无差异,但抑郁总分双感组人群更高(P<0.05);2组焦虑抑郁网络特征通过网络比较测试网络差异性检验,二者差异无统计学意义(P=0.86)。结论HIV合并结核感染者焦虑症状与单纯HIV感染者相仿,而抑郁症状程度较重,两者焦虑抑郁症状网络特征相类似。Objective To explore the network characteristics of anxiety and depression symptoms in patients with human immunodeficiency virus(HIV)/tuberculosis(TB)co-infection and those with only HIV infection.Methods A cross-sectional survey was conducted on inpatients at the Third People's Hospital of Shenzhen with HIV complicated by tuberculosis and those with only HIV infection from January 2018 to June 2023.The general patient information,disease-related data,and anxiety and depression scores as determined by the Hospital Anxiety and Depression Scale(HADS)were collected and participants were divided into HIV/TB co-infection and sole HIV infection groups in the network analysis after matching preference scores.The qgraph package was used for network visualization,with the Fruchterman-Reingold algorithm employed for generating network layouts.The differences in the network characteristics of anxiety and depression symptoms between 2 groups were compared.Results After propensity score matching,a total of 520 patient data were included in the network analysis,with 260 patients in each group.It was found that there was no significant difference in anxiety symptoms between patients with HIV/TB co-infection and those with only HIV infection,however,the total depression score was notably higher in the co-infection group(P<0.05).The network differentiation test was used to assess the network characteristics of anxiety and depression symptoms in both groups,and there was no statistically significant difference between 2 groups(P=0.86).Conclusion Anxiety symptoms in patients with HIV/TB co-infection group are similar to those in patients with sole HIV infection,however,the severity of depression symptoms is higher in the co-infection group.The network characteristics of anxiety and depression symptoms are similar between the two groups.

关 键 词：人类免疫缺陷病毒 结核 HIV合并结核 焦虑 抑郁 症状网络 

分 类 号：R473.51[医药卫生—护理学]