脯氨酸羟化酶(PHDs)对动物骨骼肌发育和脂肪沉积的调控作用及其机制  

Regulation and Mechanism of Proline Hydroxylases(PHDs)on Skeletal Muscle Development and Fat Deposition in Animals

作　　者：梁淑怡 李凡 江青艳[1] 王松波[1] LIANG Shuyi;LI Fan;JIANG Qingyan;WANG Songbo(UBT Lipid Suite Functional Fatty Acids Research Center,Guangdong Provincial Key Laboratory of Animal Nutrition Control,College of Animal Science,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]华南农业大学动物科学学院、广东省动物营养调控重点实验室、优百特脂立方功能性脂肪酸研究中心,广州510642

出　　处：《畜牧兽医学报》2024年第3期867-873,共7页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32172682,31972636)。

摘　　要：在畜禽生产中,骨骼肌发育及脂肪沉积对产品品质具有重要影响,调控骨骼肌发育和脂肪沉积以提高畜禽胴体品质和肉品质对于养殖的提质增效具有重要意义。脯氨酸羟化酶(proline hydroxylases, PHD)是一类非血红素铁依赖性双加氧酶,它不仅是缺氧诱导因子信号通路的重要调控因子,还可以通过调节细胞内氧适应水平、细胞凋亡、细胞代谢和细胞转运等方面,参与机体多种生理功能。本文在介绍PHD的生理功能及其活性调节的基础上,总结了PHDs在动物骨骼肌发育及脂肪沉积中的调控作用,分析了其发挥作用的可能机制,以期为通过调控动物骨骼肌发育和脂肪沉积来提高畜禽产品品质提供新的思路和靶点。In livestock and poultry production,skeletal muscle development and fat deposition have an important effect on product quality.Regulating skeletal muscle development and fat deposition to improve carcass quality and meat quality of livestock and poultry is of great significance for improving the quality and efficiency of breeding industry.Proline hydroxylases(PHDs)are a class of non-heme iron-dependent dioxygenases that not only act as an important regulator of hypoxic-inducing factor signaling pathway,but also participate in many physiological functions by regulating oxygen adaptation level in cells,apoptosis,cell metabolism and cell transport.On the basis of introducing the physiological function and activity regulation of PHD,this paper summarized the regulatory role of PHDs in animal skeletal muscle development and fat deposition,and analyzed the possible mechanism of its role,in order to provide new ideas and targets for improving the quality of livestock and poultry products by regulating animal skeletal muscle development and fat deposition.

关 键 词：脯氨酸羟化酶 骨骼肌发育 脂肪沉积 调控作用 

分 类 号：S852.2[农业科学—基础兽医学]