绵羊布鲁氏菌病抗病育种研究进展  

Advances of Disease-Resistant Breeding on Ovine Brucellosis

作　　者：武上杰 栾园园 王明坤 张贺春 于波 马月辉[1] 蒋琳[1] 何晓红[1] WU Shangjie;LUAN Yuanyuan;WANG Mingkun;ZHANG Hechun;YU Bo;MA Yuehui;JIANG Lin;HE Xiaohong(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Chaoyang Chaomu Breeding Stock Farm Co.Ltd.,Chaoyang 122629,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]朝阳市朝牧种畜场有限公司,朝阳122629

出　　处：《畜牧兽医学报》2024年第3期882-893,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：科技创新2030重大项目(2023ZD0405104);国家重点研发计划(2022YFD1300201);中国农业科学院创新工程计划(ASTIP-IAS01)。

摘　　要：布鲁氏菌病(brucellosis)是一种由布鲁氏菌(Brucella)感染引起的全球性人畜共患病,不仅给绵羊养殖业造成巨大的经济损失,还对公共卫生带来重大的安全隐患。布鲁氏菌具有胞内寄生和免疫逃避的能力,因此疫苗接种等常规措施难以有效防控布鲁氏菌的感染。开展绵羊布鲁氏菌病抗病新品种的选育工作,能从动物源头切断布鲁氏菌病的传播途径。本文简要阐述了布鲁氏菌依赖于毒力因子的免疫逃避机制,系统回顾了国内外布鲁氏菌病抗病育种的研究进展,包括家系群体选育、基因工程选育和标记辅助选育,并按炎症和免疫反应的发生发展阶段对候选抗病基因作了详细的梳理,以期为布鲁氏菌病的致病机制研究、抗病基因挖掘和抗病绵羊培育提供理论依据。Brucellosis is a worldwide zoonotic disease caused by Brucella,which not only induces gigantic economic losses to sheep industry,but also poses significant safety hazards to public health.Brucella possesses the capability of intracellular parasitism and immune evasion,and thus the current measure of vaccination has difficulty in effectively preventing and controling Brucella infection.Cultivating new breeds of sheep resistant to brucellosis is expected to cut off the transmission route of brucellosis from the animal origin.This paper briefly describes the immune evasion mechanism of Brucella dependent on virulence factors,and systematically reviews the research progress of brucellosis resistance breeding in China and abroad,including family-based selection,genetic engineering selection and marker-assisted selection.Furthermore,candidate disease resistance genes were organized according to the development stages of inflammation and immune response.Hoping to provide a theoretical foundation for studying the pathogenic mechanism of brucellosis,identifying disease resistance genes and breeding disease resistance sheep breeds.

关 键 词：布鲁氏菌 免疫逃避 抗病基因 抗病育种 

分 类 号：S813.2[农业科学—畜牧学]