线粒体自噬调控哺乳动物胚胎发育的研究进展  

Advances in Regulation of Mammalian Embryonic Development by Mitochondrial Autophagy

作　　者：李钰浚 何翃闳 杨丽雪 杨小耿 李键 张慧珠[2] LI Yujun;HE Honghong;YANG Lixue;YANG Xiaogeng;LI Jian;ZHANG Huizhu(Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Ministry of Education,Chengdu 610041,China;College of Animal&Veterinary Sciences,Southwest Minzu University,Chengdu 610041,China;Institute of Qinghai-Tibetan Plateau,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]青藏高原动物遗传资源保护与利用教育部重点实验室,成都610041 [2]西南民族大学畜牧兽医学院,成都610041 [3]西南民族大学青藏高原研究院,成都610041

出　　处：《畜牧兽医学报》2024年第3期905-912,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家重点研发与转化项目(2022YFD1601601);四川省科技厅重点研发计划(2023YFN0001);中央高校青年成长项目(ZYN2023051)。

摘　　要：线粒体自噬(mitophagy)是一个进化保守的过程,它可以选择性地识别、隔离和降解特定靶标。当细胞处于不利的环境下,线粒体自噬通过降解异常或过量的线粒体来维持细胞稳态,减轻细胞运行的压力。线粒体自噬在哺乳动物生殖调控过程中发挥着重要的作用,主要涉及卵母细胞的成熟、衰老和早期胚胎的发育等多种生理过程。本文主要综述了线粒体自噬的生物学功能、线粒体自噬的相关因子调控以及线粒体自噬在哺乳动物生殖中的作用机制,为进一步研究线粒体自噬在哺乳动物生殖发育过程中发挥的作用提供参考依据。Mitochondrial autophagy(mitophagy)is an evolutionarily conserved process that selectively identifies,isolates and degrades specific targets and maintain cellular homeostasis by degrading abnormal or excessive mitochondria.When cells are under adverse conditions,mitophagy eliminates excess or damaged mitochondria to maintain cellular homeostasis and reduce stress on cellular operations.Mitophagy plays an important role in regulation of mammalian reproduction,mainly involving in various physiological processes such as oocyte maturation,senescence and early embryonic development.This paper reviewed the biological functions of mitochondrial autophagy,the regulation of mitochondrial autophagy and the mechanisms of mitochondrial autophagy in mammalian reproduction,providing a reference for further studies on the role of mitochondrial autophagy in mammalian reproductive development.

关 键 词：线粒体自噬 哺乳动物 卵母细胞 胚胎 

分 类 号：S813.1[农业科学—畜牧学]