伪狂犬病病毒编码的内膜蛋白生物学功能研究进展  

Research Progress on the Biological Functions of Tegument Proteins Encoded by Pseudorabies Virus

作　　者：李艺璇 牛静轶 李港 万超 方仁东[1] 叶超[1] LI Yixuan;NIU Jingyi;LI Gang;WAN Chao;FANG Rendong;YE Chao(Joint International Research Laboratory of Animal Health and Animal Food Safety,College of Veterinary Medicine,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学动物医学院动物健康与动物性食品安全国际合作联合实验室,重庆400715

出　　处：《畜牧兽医学报》2024年第3期957-970,共14页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：中央高校基本科研业务费(SWU-KT22016);国家自然科学基金(31902256);国家生猪技术创新中心项目(NCTIP-XD/C17);重庆生猪产业技术体系项目(20211105)。

摘　　要：伪狂犬病病毒(pseudorabies virus, PRV)属于甲型疱疹病毒亚科,能够感染宿主神经系统并在神经元中建立潜伏感染,是威胁全球养猪业的重要病原体。与其他甲型疱疹病毒类似,PRV的病毒粒子存在一层富含蛋白质的内膜层,它通过将含有DNA的核衣壳与布满糖蛋白的囊膜层衔接起来构成病毒粒子的完整结构。研究表明,在PRV的感染周期中,内膜蛋白可以通过单独作用或与其他蛋白相互作用的方式,在维持病毒形态结构的稳定、促进病毒的复制和出核、参与病毒在细胞质中的二次包膜、以及对抗宿主免疫系统等方面发挥重要生物学功能。因此本文重点讨论了近年来PRV内膜蛋白生物学功能的相关研究进展,以期为伪狂犬病病毒的病原学研究以及抗病毒研究提供重要参考。Pseudorabies virus(PRV)belongs to theα-herpesvirus subfamily,which can infect the host nervous system and establish latent infection in neurons,and PRV is an important pathogen threatening the global swine industry.Similar to otherα-herpesviruses,the virion of PRV has a protein-rich inner membrane layer that links the DNA-containing capsids to the glycoprotein filled envelope layer to form the complete structure of the virion.Studies have shown that during the infection cycle of PRV,tegument proteins can play important biological functions in maintaining the stability of the morphological structure of the virus,promoting the replication and nuclear egress of the virus,participating in the secondary envelopment of the virus in the cytoplasm,and fighting against the host immune system by acting alone or interacting with other proteins.Therefore,this paper focuses on the recent research progress on the biological functions of PRV tegument proteins,in order to provide important references for the etiology and antiviral research of pseudorabies virus.

关 键 词：伪狂犬病病毒 内膜蛋白 生物学功能 

分 类 号：S852.659.1[农业科学—基础兽医学]