氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病的临床疗效  

Clinical efficacy of amlodipine combined with atorvastatin calcium tablets in the treatment of hypertension complicated with coronary heart disease

作　　者：殷音[1] YIN Yin(Department of Cardiology,the First Affiliated Hospital of Shihezi University,Shihezi 832000,China)

机构地区：[1]石河子大学第一附属医院心内科,832000

出　　处：《中国现代药物应用》2024年第5期85-88,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 分析氨氯地平联合阿托伐他汀钙片对高血压合并冠心病患者的康复所起到的积极作用。方法 78例高血压合并冠心病患者,采用随机数字表法分为对照组与观察组,每组39例。对照组采用氨氯地平治疗,观察组采用氨氯地平联合阿托伐他汀钙片治疗。对比两组血压、血脂、临床治疗效果、并发症发生率、自我护理能力[自我护理能力量表(ESCA)评分]及生活质量水平[生活质量量表(QOL)评分]。结果 治疗后,两组收缩压和舒张压均较治疗前降低,且观察组收缩压(122.23±10.74)mm Hg(1 mm Hg=0.133 kPa)和舒张压(87.58±9.86)mm Hg低于对照组的(137.69±12.56)、(95.86±8.05)mm Hg,差异显著(P<0.05)。观察组总胆固醇(3.06±0.36)mmol/L、低密度脂蛋白胆固醇(1.51±0.21)mmol/L、甘油三酯(1.54±0.14)mmol/L均低于对照组的(4.14±0.74)、(1.87±0.16)、(2.03±0.06)mmol/L,高密度脂蛋白胆固醇(1.54±0.14)mmol/L高于对照组的(1.25±0.13)mmol/L,差异显著(P<0.05)。观察组治疗总有效率94.87%显著高于对照组的74.36%,差异显著(P<0.05)。观察组不良反应发生率7.69%显著低于对照组的28.21%,差异显著(P<0.05)。治疗后,观察组ESCA评分(123.45±12.63)分及QOL评分(57.56±6.13)分高于对照组的(108.23±10.65)、(48.52±6.22)分,差异显著(P<0.05)。结论 氨氯地平联合阿托伐他汀钙片用于高血压合并冠心病治疗中,取得了良好的疾病治疗效果。Objective To analyze the active effect of amlodipine combined with atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease.Methods 78 patients with hypertension and coronary heart disease were divided into a control group and an observation group by random number table method,with 39 cases in each group.The control group was treated with amlodipine,and the observation group was treated with amlodipine and atorvastatin calcium tablets.The blood pressure,blood lipids,clinical effect,incidence of complications,self-care ability[self-care ability scale(ESCA)score]and quality of life(QOL)score of the two groups were compared.Results After treatment,the systolic blood pressure and diastolic blood pressure in both groups were lower than those before treatment;the systolic blood pressure of(122.23±10.74)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure of(87.58±9.86)mm Hg in the observation group were lower than(137.69±12.56)and(95.86±8.05)mm Hg in the control group;the difference was significant(P<0.05).The observation group had total cholesterol of(3.06±0.36)mmol/L,low density lipoprotein cholesterol of(1.51±0.21)mmol/L,triglyceride of(1.54±0.14)mmol/L,which were lower than(4.14±0.74),(1.87±0.16),(2.03±0.06)mmol/L in the control group;the high density lipoprotein cholesterol of(1.54±0.14)mmol/L in the observation group was higher than(1.25±0.13)mmol/L in the control group;the difference was significant(P<0.05).The total effective rate of 94.87%in the observation group was significantly higher than 74.36%in the control group(P<0.05).The incidence of adverse reactions in the observation group was 7.69%,which was significantly lower than 28.21%in the control group(P<0.05).After treatment,ESCA score of(123.45±12.63)points and QOL score of(57.56±6.13)points in the observation group were higher than(108.23±10.65)and(48.52±6.22)points in the control group,and the difference was significant(P<0.05).Conclusion Amlodipine combined with atorvastatin calcium tablets

关 键 词：高血压 冠心病 氨氯地平 阿托伐他汀钙片 血压 血脂 并发症 治疗效果 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学] R969[医药卫生—临床医学]