尿毒清颗粒联合缬沙坦胶囊治疗糖尿病肾病大量蛋白尿的临床研究  

Clinical Study of Urine Duqing Granule Combined with Valsartan Capsule in the Treatment of Diabetic Nephropathy with Massive Proteinuria

作　　者：阮泽琼 张旭 RUAN Zeqiong;ZHANG Xu(Department of Nephrology,Xuyi County People's Hospital,Xuyi,Jiangsu Province,211700 China;Department of Nephrology,Xuyi County Hospital of Traditional Chinese Medicine,Xuyi,Jiangsu Province,211700 China)

机构地区：[1]江苏省盱眙县人民医院肾内科,江苏盱眙211700 [2]江苏省盱眙县中医院肾内科,江苏盱眙211700

出　　处：《糖尿病新世界》2024年第1期91-93,97,共4页Diabetes New World Magazine

摘　　要：目的 探究尿毒清颗粒联合缬沙坦胶囊在糖尿病肾病患者大量蛋白尿治疗中的临床效果。方法 选取2020年5月—2023年6月江苏省盱眙县人民医院肾内科收治的64例血肌酐在108~265μmol/L的糖尿病肾病合并大量蛋白尿患者为研究对象,根据抛硬币法分为对照组和研究组,均接受常规降糖药物二甲双胍治疗,对照组(n=32)采用钠-葡萄糖协同转运蛋白2抑制剂治疗,研究组(n=32)采用缬沙坦联合尿毒清颗粒治疗。连续30 d治疗后,比较两组治疗效果。结果 研究组治疗总有效率为93.75%,高于对照组的71.88%,差异有统计学意义(χ^(2)=5.379,P<0.05);研究组的24 h尿微量蛋白、24 h尿蛋白定量、血肌酐、血尿素氮水平均优于对照组,差异有统计学意义(P均<0.05);研究组空腹血糖和餐后2 h血糖水平均低于对照组,差异有统计学意义(P均<0.05)。结论 尿毒清颗粒配合缬沙坦胶囊可改善糖尿病肾病大量蛋白尿和肾功能指标,提高临床治疗有效性,保证患者用药后获取理想疗效。Objective To explore the clinical effect of urine Duqing granule combined with valsartan capsule in the treatment of diabetic nephropathy patients with massive proteinuria.Methods 64 patients with diabetic nephropathy between 108 to 265μmol/L with blood creatinine admitted to the department of nephrology of Xuyi County People's Hospital of Jiangsu Province from May 2020 to June 2023 were selected as the research objects.They were divided into control group and study group according to com-toss methods,all treated with the conventional hypoglycemic drug metformin,in the control group(n=32)were treated with sodium-glucose cotransporter 2 inhibitor,and in the study group(n=32)were treated with valsartan and urine Duqing granule.After 30 d of consecutive treatment,the treatment effects of the two groups were compared.Results The total response rate of the study group was 93.75%,which was higher than 71.88%in the control group,and the difference was statistically significant(χ^(2)=5.379,P<0.05).The levels of 24 h urine trace protein,24 h urine protein quantification,blood creatinine and blood urea nitrogen were better than those of the control group,and the differences were statistically significant(all P<0.05);fasting fasting glu-cose and 2-hour postprandial glucose levels of the study group were lower than those of the control group,and the dif-ferences were statistically significant(both P<0.05).Conclusion The combination of urine Duqing granule and valsar-tan capsule can improve the indexes of proteinuria and renal function in diabetic nephropathy,improve the effective-ness of clinical treatment,and ensure the ideal curative effect of patients after medication.

关 键 词：尿毒清颗粒 缬沙坦胶囊 糖尿病肾病 大量蛋白尿 肾功能 

分 类 号：R4[医药卫生—临床医学]