自拟排浊清宫汤配方颗粒联合米索前列醇片对产后宫内组织残留患者子宫复旧的影响  

Effect of self-prescribed Paizhuo Qinggong Herbal Formula Granule combined with Misoprostol Tablets on uterine recovery in patients with residual intrauterine tissue after childbirth

作　　者：张佳丽 易宏英[2] 郝玲 李尚文 陈昶旭[1] ZHANG Jiali;YI Hongying;HAO Ling;LI Shangwen;CHEN Changxu(Department of Traditional Chinese Medicine,Sichuan Provincial Maternal and Child Health Hospital,Chengdu,Sichuan,610045;Department of Gynecology,Sichuan Provincial Maternal and Child Health Hospital,Chengdu,Sichuan,610045)

机构地区：[1]四川省妇幼保健院中医科,四川成都610045 [2]四川省妇幼保健院妇科,四川成都610045

出　　处：《实用临床医药杂志》2024年第4期55-60,共6页Journal of Clinical Medicine in Practice

基　　金：中国妇幼保健协会-华润三九中医中西医结合妇幼健康专项研究基金项目(ZXY2020A05)。

摘　　要：目的探讨自拟排浊清宫汤配方颗粒联合米索前列醇片对产后宫内组织残留患者子宫复旧的影响。方法采用随机、盲法、安慰剂平行对照法选取120例产后患者为研究对象,依据简单随机化法分为对照组60例、试验组60例。对照组予以中药配方颗粒安慰剂联合米索前列醇片治疗,试验组予以自拟排浊清宫汤配方颗粒联合米索前列醇片治疗。统计2组临床疗效、中医证候积分、宫内组织物残留面积、子宫复旧指标(子宫三径之和、子宫底下降速度)、超声血流参数、基质金属蛋白酶-9(MMP-9)、特异性组织抑制物-1(TIMP-1)、阴道出血情况、不良反应发生情况及清宫率。结果试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗1、2周后,2组中医证候积分、宫内组织物残留面积与治疗前比较,差异有统计学意义(P<0.05);试验组治疗1、2周后中医证候积分、宫内组织物残留面积均低于对照组,差异有统计学意义(P<0.05)。2组治疗1、2周后子宫三径之和与治疗前比较,差异有统计学意义(P<0.05);试验组治疗1、2周后子宫三径之和低于对照组,差异有统计学意义(P<0.05)。试验组子宫底下降速度高于对照组,差异有统计学意义(P<0.05)。2组治疗1、2周后宫螺旋动脉阻力指数(RI)、舒张期峰值血流速度(EDV)、收缩期峰值血流速度(PSV)、搏动指数(PI)与治疗前比较,差异有统计学意义(P<0.05);试验组治疗1、2周后EDV、PSV低于对照组,RI、PI高于对照组,差异有统计学意义(P<0.05)。2组治疗1、2周后血清MMP-9、TIMP-1含量与治疗前比较,差异有统计学意义(P<0.05);试验组治疗1、2周后血清MMP-9、TIMP-1含量低于对照组,差异有统计学意义(P<0.05)。试验组阴道出血时间短于对照组,阴道出血量优于对照组,差异有统计学意义(P<0.05)。试验组清宫率低于对照组,差异有统计学意义(P<0.05)。结论自拟排浊清宫汤配方颗�Objective To investigate the effect of self-prescribed Paizhuo Qinggong Herbal Formula Granule combined with Misoprostol Tablets on uterine recovery in patients with residual intrauterine tissue after childbirth.Methods A total of 120 patients with residual intrauterine tissue after childbirth were randomly selected.According to the simple randomization method,60 patients were assigned to control group(n=60) and experimental group(n=60).In the control group,patients were treated with a placebo of traditional Chinese medicine formula granules combined with Misoprostol Tablets.In the experimental group,patients were treated with self-prescribed Paizhuo Qinggong Herbal Formula Granule combined with Misoprostol Tablets.The clinical efficacy,syndrome score of traditional Chinese medicine,residual area of intrauterine tissue,uterine recovery indicators(sum of three uterine diameters and rate of uterine fundus descent),ultrasound blood flow parameters,matrix alloproteinase-9( MMP-9),tissue inhibitor of metalloproteinase-1( TIMP-1),vaginal bleeding,adverse reactions,and uterine curettage rate were analyzed.Results The total effective rate of treatment in the experimental group was higher than that in the control group( P < 0.05).After 1 week and 2weeks of treatment,there were statistically significant differences in the syndrome score of traditional Chinese medicine and residual area of intrauterine tissue compared with those before treatment( P <0.05).The syndrome score of traditional Chinese medicine and residual area of intrauterine tissue in the experimental group were lower than those in the control group after 1 week and 2 weeks of treatment( P < 0.05).There were statistically significant differences in the sum of three uterine diameters between the two groups after 1 week and 2 weeks of treatment compared with those before treatment( P < 0.05).The sum of three uterine diameters in the experimental group was lower than that in the control group after 1 week and 2 weeks of treatment( P < 0.05).The rate of uterine fu

关 键 词：排浊清宫汤配方颗粒 米索前列醇片 子宫复旧 产后 宫内组织残留 疗效 阴道出血 

分 类 号：R714.462[医药卫生—妇产科学] R246.3[医药卫生—临床医学] R445.1