开滦研究人群全血铁与高尿酸血症的关联性研究  

Relationship between whole blood iron and hyperuricemia in Kailuan study population

作　　者：王洁蕊 朱保杰[1] 王丽 石慧婧[2] 崔刘福 舒荣[2] 宋海澄[2] 徐爱刚[4] 张艳淑 WANG Jierui;ZHU Baojie;WANG Li;SHI Huijing;CUI Liufu;SHU Rong;SONG Haicheng;XU Aigang;ZHANG Yanshu(School of Public Health,North China University of Science and Technology,Tangshan,Hebei 063210,China;不详)

机构地区：[1]华北理工大学公共卫生学院,河北唐山063210 [2]开滦总医院风湿免疫科,河北唐山063000 [3]中国医学科学院基础医学研究所北京协和医学院基础学院,北京100730 [4]开滦总医院林西医院急诊科,河北唐山063100

出　　处：《中华全科医学》2024年第3期398-401,共4页Chinese Journal of General Practice

基　　金：河北省医学科学研究课题(20231857)。

摘　　要：目的 探讨开滦研究人群全血铁与高尿酸血症的关联,为早期预防高尿酸血症提供依据。方法 采用横断面研究,研究对象选自2017年8月—2018年5月在林西医院、马家沟医院、荆各庄医院参加健康体检且完成全血铁检测的开滦集团在职和离退休职工,其中符合入选标准的研究对象共3 579人。按血尿酸水平分为正常血尿酸组(2 983例)和高尿酸血症组(596例),采用多因素logistic回归模型分析全血铁(按照三分位分为Q1~Q3三个亚层)与高尿酸血症的关联,并分析不同年龄对全血铁与高尿酸血症关联的影响。结果 高尿酸血症组全血铁[(464.73±104.05)mg/L]显著高于正常血尿酸组[(420.96±109.60)mg/L],差异有统计学意义(P<0.001)。多因素logistic回归分析显示,在调整其他混杂因素后,与全血铁Q1组相比,全血铁Q3组发生高尿酸血症的OR值(95%CI)为1.989(1.487~2.661)。在<60岁的研究对象中,与全血铁Q1组相比,全血铁Q3组发生高尿酸血症的OR值(95%CI)为2.304(1.539~3.450);而在≥60岁的研究对象中,与全血铁Q1组相比,全血铁Q3组发生高尿酸血症的OR值(95%CI)为1.269(0.818~1.969)。在敏感性分析中,与全血铁Q1组相比,全血铁Q3组发生高尿酸血症的OR值(95%CI)为2.018(1.499~2.716)。结论 较高的全血铁水平与高尿酸血症风险增加相关,且在年龄<60岁的人群中有显著关联。Objective To explore the relationship between whole blood iron level and hyperuricemia in Kailuan study population,and to provide evidence for the early prevention of hyperuricemia.Methods A cross-sectional study was conducted in 3 579 employees and retirees of Kailuan Group who participated in the health examination and completed the whole blood iron test in Linxi Hospital,Majiagou Hospital and Jinggezhuang Hospital from August,2017 to May,2018.According to the level of serum uric acid,the subjects were divided into normal serum uric acid group(n=2 983) and hyperuricemia group(n=596).Multivariate logistic regression model was used to analyze the association between whole blood iron(divided into Q1 to Q3 three subgroups according to tertiles) and hyperuricemia,and the effect of different ages on the association between whole blood iron and hyperuricemia was analyzed.Results The whole blood iron in hyperuricemia group [(464.73±104.05) mg/L] was significantly higher than that in normal serum uric acid group [(420.96±109.60) mg/L,P<0.001].Multivariate logistic regression analysis showed that after adjusting for other confounding factors,compared with the whole blood iron Q1 group,the OR value(95% CI) of hyperuricemia in the whole blood iron Q3 group was 1.989(1.487-2.661).In the subjects aged <60 years,the OR value(95% CI) of hyperuricemia in the whole blood iron Q3 group was 2.304(1.539-3.450),while which was 1.269(0.818-1.969) in the subjects aged ≥60 years.In sensitivity analysis,compared with the whole blood iron Q1 group,the OR value(95% CI) of hyperuricemia in the whole blood iron Q3 group was 2.018(1.499-2.716).Conclusion Higher whole blood iron level is associated with an increased risk of hyperuricemia,especially in people younger than 60 years old.

关 键 词：血尿酸 高尿酸血症 全血铁 开滦研究人群 

分 类 号：R446.1[医药卫生—诊断学] R589.7[医药卫生—临床医学]