难治性支原体肺炎患儿血清LncRNA NNT-AS1、IL-17A水平变化及临床意义  

Changes and clinical significance of serum LncRNA NNT-AS1,IL-17A levels in children with refractory mycoplasma pneumonia

作　　者：闫静 侯艳苗 王振华 YAN Jing;HOU Yanmiao;WANG Zhenhua(Department of Pediatrics,Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou,Hebei 075000,China)

机构地区：[1]张家口市妇幼保健院儿科,河北张家口075000

出　　处：《中华全科医学》2024年第3期447-450,468,共5页Chinese Journal of General Practice

基　　金：河北省中医药管理局科研计划项目(2022533)。

摘　　要：目的 探讨血清LncRNA NNT-AS1、白细胞介素(IL)17A在难治性肺炎支原体肺炎(RMPP)患儿中的表达及临床应用价值。方法 选取2021年2月—2022年3月张家口市妇幼保健院诊治的148例MPP患儿(MPP组),根据是否发生RMPP分为RMPP组(48例)和非RMPP组(100例),以同期60例择期行鞘膜积液手术的患儿为对照组。比较各组血清LncRNA NNT-AS1、IL-17A的差异。采用Pearson相关分析研究血清LncRNA NNT-AS1、IL-17A与炎性指标的相关性。采用多因素logistic回归分析研究影响RMPP发病的因素。采用受试者工作特征曲线分析LncRNA NNT-AS1、IL-17A对RMPP发病的预测价值。结果 MPP组血清LncRNA NNT-AS1、IL-17A均高于对照组(P<0.05)。MPP组血清LncRNA NNT-AS1、IL-17A与CRP、PCT、IL-6、TNF-α均呈正相关关系(r=0.623~0.721,P<0.001)。血清LncRNA NNT-AS1、IL-17A升高是影响RMPP发病的独立危险因素。两者联合对MPP患儿发生RMPP的曲线下面积为0.906,优于单独检测。结论 RMPP患儿血清LncRNA NNT-AS1、IL-17A水平升高,是影响RMPP发病的独立危险因素,两者联合检测有助于评估RMPP的发生。Objective To investigate the expression and clinical value of serum LncRNA NT-AS1 and interleukin(IL) 17A in children with refractory mycoplasma pneumoniae pneumonia(RMPP).Methods A total of 148 children with MPP(MPP group) diagnosed and treated at Zhangjiakou Maternal and Child Health Hospital from February 2021 to March 2022 were selected and divided into RMPP group(48 cases) and non-RMPP group(100 cases) according to whether RMPP occurred.Sixty children who underwent surgery for hydrocele in the same period were selected as the control group.The differences of serum LncRNA NNT-AS1 and IL-17A between all groups were compared.The correlation between serum LncRNA NNT-AS1,IL-17A and inflammatory markers was analyzed by Pearson correlation analysis.Multivariate logistic regression analysis of factors affecting the incidence of RMPP.The predictive value of LncRNA NNT-AS1 and IL-17A in the incidence of RMPP was analyzed by subject operating characteristic curve.Results Serum LncRNA NNT-AS1 and IL-17A in the MPP group were higher than those in the control group(P<0.05).Serum LncRNA NNT-AS1 and IL-17A in the MPP group were positively correlated with CRP,PCT,IL-6 and TNF-α(r=0.623-0.721,P<0.001).Elevated levels of serum LncRNA NNT-AS1 and IL-17A were independent risk factors for RMPP.The area under the curve of RMPP in MPP children was 0.906,which was better than that of single detection.Conclusion The elevated levels of serum LncRNA NNT-AS1 and IL-17A in children with RMPP are independent risk factors for the development of RMPP,and the combined detection of LncRNA NNT-AS1 and IL-17A is helpful in assessing the occurrence of RMPP.

关 键 词：难治性肺炎支原体肺炎 长链非编码RNA NNT-AS1 白细胞介素17A 预测价值 

分 类 号：R563.1[医药卫生—呼吸系统] R518.9[医药卫生—内科学]