基于定量CT的机会性骨质疏松诊断:2种定量CT骨密度测量软件临床应用比较分析  

Quantitative computed tomography-based opportunistic osteoporosis diagnosis:a comparison of clinical applications of two quantitative CT softwares

作　　者：赵君禄[1] 刘斋[1] 韩康 赵德园 任庆云[1] ZHAO Jun-lu;LIU Zhai;HAN Kang;ZHAO De-yuan;REN Qing-yun(Department of Radiology and Nuclear Medicine,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China)

机构地区：[1]河北医科大学第一医院放射与核医学科,河北石家庄050031

出　　处：《河北医科大学学报》2024年第1期17-23,共7页Journal of Hebei Medical University

基　　金：河北省财政厅政府资助专科能力建设和专科带头人培养项目(LS201804)。

摘　　要：目的探讨FTHK定量CT骨密度测量软件和Mindways(MW)定量CT Pro骨密度测量软件测量腰椎骨密度(bone mineral density,BMD)的重复性、可靠性、一致性及其在临床中的应用价值。方法选择临床需要进行常规腹部CT扫描患者708例,将扫描数据分别传到FTHK和MW骨密度测量软件进行测量,对2组测量结果采用配对样本t检验、Pearson相关性分析、组内相关系数(intraclass correlation coefficient,ICC)、Bland-Altman分析及Cronbach′sα系数统计学方法进行分析。结果FTHK和MW 2种软件测量BMD的ICC分别为0.976及0.936。FTHK软件BMD值(126.29±50.16)mg/cm~3高于MW软件BMD值(112.85±46.02)mg/cm~3,两者的平均差值为10.6%(P<0.05)。FTHK软件对OP的检出率(19.63%)低于MW软件测量(25.42%)(P<0.05)。FTHK软件BMD与MW软件测量BMD之间呈显著正相关(r=0.955,P<0.01),Bland-Altman分析显示BMD差值的95%位于差值平均值±1.96标准差范围内。FTHK软件Cronbach′sα系数=0.963,MW软件Cronbach′sα系数=0.988。结论FTHK骨密度测量分析软件与MW骨密度测量软件的一致性及可信度好,可用于常规腹部CT扫描患者的机会性骨质疏松诊断。Objective To explore the reproducibility,reliability,and consistency of lumbar bone mineral density(BMD)measured by FTHK software and Mindways(MW)quantitative CT Pro software and its application in clinical practice.Methods A total of 708 patients who needed to undergo conventional abdominal CT scan were selected,and scan data were transmitted to FTHK and MW bone densitometry software for measurement.The paired-sample t-test,Pearson correlation analysis,intraclass correlation coefficient(ICC),Bland-Altman analysis,and Cronbach′sαcoefficient were used to analyze the measurement results of the two groups.Results ICC of both the FTHK and MW software for measurement of BMD was 0.976 and 0.936,respectively.The BMD value[(126.29±50.16)mg/cm~3]measured by FTHK was higher than that[(112.85±46.02)mg/cm~3]measured by MW,and the difference was 10.6%(P<0.05).The detection rate of OP by FTHK software(19.63%)was lower than that measured by MW software(25.42%)(P<0.05).There was a significant positive correlation in BMD values between the FTHK and MW analyses(r=0.955,P<0.01).According to the results of Bland-Altman analysis,the difference of 95%was within the±1.96 standard deviation of the average difference value.The FTHK had a Cronbach′sαcoefficient=0.963,and the MW had a Cronbach′sαcoefficient=0.988.Conclusion The reliability and consistency of BMD measured by the FTHK and MW are good,and they can be used for the diagnosis of opportunistic osteoporosis.

关 键 词：骨质疏松 骨密度 体层摄影术 X线计算机 

分 类 号：R681[医药卫生—骨科学]