替米沙坦联合硝苯地平控释片对冠心病合并轻中度高血压患者左心室功能及炎症反应的影响  

Effects of telmisartan combined with nifedipine controlled-release tablets on left ventricular function and inflammatory response in patients with coronary heart disease and mild to moderate hypertension

作　　者：刘爱霞[1] LIU Ai-xia(Handan Fourth Hospital,Handan 056200,China)

机构地区：[1]邯郸市第四医院,056200

出　　处：《中国实用医药》2024年第5期104-106,共3页China Practical Medicine

摘　　要：目的探究冠心病合并轻中度高血压患者采用替米沙坦+硝苯地平控释片治疗对患者左心室功能及炎症反应的影响。方法选择108例冠心病合并轻中度高血压患者,按随机数字表法分为对照组和观察组,各54例。对照组给予硝苯地平控释片治疗,观察组在对照组基础上加用替米沙坦治疗。比较两组血压[舒张压(DBP)及收缩压(SBP)]、心功能[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)]、炎症反应[肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)]及安全性。结果治疗前,两组DBP、SBP比较,差异无统计学意义(P>0.05);治疗后,观察组DBP(78.22±6.79)mm Hg(1mm Hg=0.133 kPa)、SBP(124.14±9.95)mm Hg均低于对照组的(84.57±8.02)、(140.69±11.20)mm Hg,差异有统计学意义(P<0.05)。治疗前,两组LVEDD、LVEF、LVESD比较,无统计学差异(P>0.05);治疗后,观察组LVEDD(51.43±6.13)mm、LVESD(43.13±6.97)mm均小于对照组的(54.13±5.89)、(46.42±6.95)mm,LVEF(52.84±7.46)%大于对照组的(49.48±6.97)%,有统计学差异(P<0.05)。治疗前,两组TNF-α、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,观察组TNF-α(39.38±9.85)ng/L、hs-CRP(6.32±0.88)mg/L均低于对照组的(51.29±8.38)ng/L、(8.98±1.28)mg/L,差异有统计学意义(P<0.05)。两组均未出现严重不良反应。结论冠心病合并轻中度高血压患者采用替米沙坦联合硝苯地平控释片治疗能够有效缓解炎症反应,调节血压,改善心功能,且安全性高。Objective To explore the effect of telmisartan combined with nifedipine controlled-release tablets on left ventricular function and inflammatory response in patients with coronary heart disease and mild to moderate hypertension.Methods 108 patients with coronary heart disease complicated with mild to moderate hypertension were randomly divided into a control group and an observation group,with 54 patients in each group.The control group was treated with nifedipine controlled-release tablets,and the observation group was treated with telmisartan.Comparison was made on blood pressure[diastolic blood pressure(DBP)and systolic blood pressure(SBP)],cardiac function[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)],inflammatory response[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)]and safety between the two groups.Results Before treatment,there was no significant difference in DBP and SBP between the two groups(P>0.05).After treatment,DBP of(78.22±6.79)mm Hg(1 mm Hg=0.133 kPa)and SBP of(124.14±9.95)mm Hg in the observation group were lower than(84.57±8.02)and(140.69±11.20)mm Hg in the control group.The difference was statistically significant(P<0.05).Before treatment,there were no significant differences in LVEDD,LVEF and LVESD between the two groups(P>0.05).After treatment,LVEDD of(51.43±6.13)mm and LVESD of(43.13±6.97)mm in the observation group were lower than(54.13±5.89)and(46.42±6.95)mm in the control group;LVEF of(52.84±7.46)%in the observation group was higher than(49.48±6.97)%in the control group.There was statistical difference(P<0.05).Before treatment,there was no significant difference in the levels of TNF-αand hs-CRP between the two groups(P>0.05).After treatment,TNF-αof(39.38±9.85)ng/L and hs-CRP of(6.32±0.88)mg/L in the observation group were lower than(51.29±8.38)ng/L and(8.98±1.28)mg/L in the control group,and the difference was statistically significant(P<0.05).No serious a

关 键 词：冠心病 轻中度高血压 替米沙坦 硝苯地平控释片 心功能 炎症反应 

分 类 号：R541.4[医药卫生—心血管疾病] R544.1[医药卫生—内科学]