硝苯地平与利托君治疗先兆早产的临床效果评价  

Clinical efficacy evaluation of nifedipine and ritodrine in the treatment of threatened premature delivery

作　　者：许力分 XU Li-fen(Department of Obstetrics and Gynecology,Longzhou County People's Hospital,Chongzuo 532400,China)

机构地区：[1]广西龙州县人民医院妇产科,532400

出　　处：《中国实用医药》2024年第5期107-110,共4页China Practical Medicine

摘　　要：目的 探索分析先兆早产孕妇予以硝苯地平、利托君治疗的效果。方法 将90例先兆早产孕妇作为研究对象,以数字随机法分为对照组和研究组,各45例。对照组予以利托君进行治疗,研究组予以硝苯地平进行治疗。比较两组孕妇治疗后宫缩抑制情况,治疗过程中不良反应发生情况,药物起效时间以及妊娠延长时间,妊娠结局及新生儿情况。结果 研究组宫缩总抑制率为84.44%,略高于对照组的75.56%(P>0.05)。研究组治疗过程中不良反应发生率仅为4.44%,显著低于对照组的17.78%(P<0.05)。研究组药物起效时间(2.53±0.51)h以及妊娠延长时间(26.43±2.82)d均明显优于对照组的(2.82±0.49)h、(27.94±3.78)d(P<0.05)。研究组保胎成功率高达95.56%,显著超过对照组的82.22%(P<0.05);两组新生儿体重无显著差异(P>0.05);研究组1 min Apgar评分(9.68±0.25)分显著超过对照组的(9.24±0.32)分(P<0.05)。结论 针对先兆早产孕妇予以硝苯地平、利托君治疗,均可以有效抑制宫缩、延长分娩时间、改善妊娠以及新生儿结局,较之于利托君,硝苯地平效果更好、安全性更高,值得推广应用。Objective To explore and analyze the effect of nifedipine and ritodrine in the treatment of threatened premature delivery.Methods 90 pregnant women with threatened premature delivery were divided into a control group and a study group by random numerical method,with 45 cases in each group.The control group was treated with ritodrine,and the study group was treated with nifedipine.The suppression of uterine contraction after treatment,occurrence of adverse reactions during treatment,time to drug onset,prolongation of pregnancy,pregnancy outcome and neonatal condition were compared between the two groups.Results The total inhibition rate of contractions in the study group was 84.44%,which was slightly higher than 75.56%in the control group(P>0.05).The incidence of adverse reactions during treatment in the study group was only 4.44%,which was significantly lower than 17.78%in the control group(P<0.05).The study group had time to drug onset of(2.53±0.51)h and prolongation of pregnancy of(26.43±2.82)d,which were significantly better than(2.82±0.49)h and(27.94±3.78)d in the control group(P<0.05).The success rate of fetal preservation of the study group was 95.56%,which was significantly higher than 82.22%of the control group(P<0.05).There was no significant difference in neonatal weight between the two groups(P>0.05).The 1-min Apgar score of the study group was(9.68±0.25)points,which was significantly higher than(9.24±0.32)points of the control group(P<0.05).Conclusion Nifedipine combined with ritodrine for pregnant women with threatened premature delivery can effectively inhibit uterine contraction,prolong labor time,and improve pregnancy and neonatal outcomes.Compared with ritodrine,nifedipine has better effect and higher safety,and is worthy of promotion and application.

关 键 词：利托君 硝苯地平 先兆早产 宫缩抑制 不良反应 妊娠时间 新生儿结局 

分 类 号：R714.21[医药卫生—妇产科学]