TG/Cys-C联合MDA水平在2型糖尿病合并肾病患者中的诊断价值  

Diagnostic value of TG/Cys-C ratio combined with MDA level in patients withtype 2 diabetes mellitus complicated with nephropathy

作　　者：褚丽 任传路[1] 丁俊[2] 肖立[1] 吴薇 周忻[1] CHU Li;REN Chuan-lu;DING Jun;XIAO Li;WU Wei;ZHOU Xin(Department of Laboratory,the 904th Hospital of the Joint Logistics Support Force of PLA,Jiangsu Province,Wuxi 214044,China;Department of Urology,the 904th Hospital of the Joint Logistics Support Force of PLA,Jiangsu Province,Wuxi 214044,China)

机构地区：[1]中国人民解放军联勤保障部队第九○四医院检验科,江苏无锡214044 [2]中国人民解放军联勤保障部队第九○四医院泌尿外科,江苏无锡214044

出　　处：《河北医科大学学报》2024年第3期368-372,共5页Journal of Hebei Medical University

基　　金：江苏省卫生健康委医学科研项目(M2021090)。

摘　　要：目的探究三酰甘油/胱抑素C(triglyceride/cystatin C,TG/Cys-C)比值联合丙二醛(malondialdehyde,MDA)水平在2型糖尿病(type 2 diabetes,T2DM)患者中的的诊断价值。方法收集T2DM患者300例的临床资料,根据患者是否并发肾病分为T2DM组及糖尿病肾病(diabetes kidney disease,DKD)组。分析T2DM患者并发肾病的影响因素,检测三酰甘油(triglyceride,TG)、胱抑素C(cystatin C,Cys-C)及MDA水平,ROC分析TG/Cys-C、MDA水平及联合对于T2DM患者并发肾病的诊断价值。结果T2DM并发肾病组TG/Cys-C比值低于T2DM组,MDA、尿白蛋白/肌酐比值(albumin/creatinine ratio,ACR)、血肌酐(serum creatinine,SCr)水平高于T2DM组,差异有统计学意义(P<0.05),经Logistic回归分析,TG/Cys-C比值及MDA水平是T2DM患者并发肾病的独立危险因素(P<0.05),TG/Cys-C比值及MDA水平对T2DM患者并发肾病诊断的AUC值分别为0.809,0.837,95%CI:0.760~0.852,0.791~0.877;二者联合诊断的AUC值为0.915,95%CI:0.877~0.944。结论TG/Cys-C比值及MDA水平对于T2DM患者并发肾病的诊断均有一定的参考价值,二者联合用于T2DM患者并发肾病诊断的价值更高。Objective To investigate the diagnostic value of triglyceride/cystatin C(TG/Cys-C)ratio combined with malondialdehyde(MDA)level in patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 300 patients with T2DM were collected,and the patients were divided into T2DM group and diabetic kidney disease(DKD)group according to complication of kidney disease.The influencing factors of DKD in T2DM patients were analyzed,and the levels of triglycerides(TG),cystatin C(Cys-C),and MDA were detected.The diagnostic value of the levels of TG/Cys-C and MDA alone and in combination for the diagnosis of DKD in T2DM patients was analyzed by receiver operating characteristic(ROC)curve.Results The TG/Cys C ratio in the T2DM and DKD group was lower than that in the T2DM group,while the levels of MDA,ACR,and SCR were higher than those in the T2DM group,with statistical significance(P<0.05).Logistic regression analysis showed that the TG/Cys C ratio and MDA level were independent risk factors for T2DM and DKD patients(P<0.05).The area under the ROC curve(AUC)values of TG/Cys C ratio and MDA level for the diagnosis of T2DM patients with nephropathy were 0.809 and 0.837 respectively(95%CI:0.760-0.852,0.791-0.877,respectively).The AUC value for the combined diagnosis of the two was 0.915(95%CI:0.877-0.944).Conclusion Both TG/Cys-C ratio and MDA levels have certain reference value for the diagnosis of DKD in T2DM patients,and the combination of TG/CyS-C ratio and MDA level is of higher value for the diagnosis of DKD in T2DM patients.

关 键 词：糖尿病 2型 糖尿病肾病 影响因素 

分 类 号：R587.1[医药卫生—内分泌]