结核特异性T淋巴细胞共信号分子的功能研究进展  

Advances in the co-signal molecular function of Mtb-specific T lymphocytes

作　　者：仝静 李姗姗 逄宇 高孟秋[2] Tong Jing;Li Shanshan;Pang Yu;Gao Mengqiu(Department of Bacteriology and Immunology,Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis&Thoracic Tumor Research Institute,Beijing 101149,China;Department of Tuberculosis,Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis&Thoracic Tumor Research Institute,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所细菌免疫学实验室,北京101149 [2]首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所结核二区,北京101149

出　　处：《中华结核和呼吸杂志》2024年第3期275-281,共7页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：首都临床诊疗技术研究与示范应用(Z191100006619077)。

摘　　要：T淋巴细胞上的共刺激受体和共抑制受体在机体的免疫应答中发挥着重要作用。不断有证据表明,在感染、肿瘤、自身免疫等疾病中T细胞表面共信号分子的表达改变,对共信号分子进行干预可用于疾病的免疫治疗。本文对结核特异性T淋巴细胞上的共刺激受体和共抑制受体进行综述,进一步阐释共信号分子在结核病中发挥的作用机制,为未来深入研究和临床应用提供参考。Costimulatory and co-inhibitory receptors on T lymphocytes play an essential role in the immune response.There is increasing evidence that the expression of co-signal molecules on T cells is altered in infection,tumor,autoimmunity,and other diseases,and that intervention of co-signal molecules can be used in the immunotherapy.This paper reviewed the costimulatory and coinhibitory receptors on Mtb-specific T lymphocytes and further explained the mechanism of co-signal molecules in the progression of tuberculosis,to provide a reference for future research and clinical application.

关 键 词：共信号分子 自身免疫 免疫治疗 免疫应答 T淋巴细胞 结核病 共抑制受体 临床应用 

分 类 号：R52[医药卫生—内科学]