赖诺普利与沙库巴曲缬沙坦对射血分数保留心衰患者的疗效对比  

Comparison of Lisinopril and Sacubitril-Valsartan in Heart Failure Patients with Preserved Ejection Fraction

作　　者：王占永 Wang Zhanyong(Xinye County People′s Hospital,Nanyang,Henan 473500)

机构地区：[1]新野县人民医院,河南南阳473500

出　　处：《辽宁医学杂志》2024年第1期23-26,共4页Medical Journal of Liaoning

摘　　要：目的探讨赖诺普利与沙库巴曲缬沙坦对射血分数保留心衰患者的疗效。方法选取我院2020年1月~2022年2月82例接受诊治并确诊为射血分数保留心衰患者作为研究对象,随机分为观察和对照两组,两组均为41例。观察组给予沙库巴曲缬沙坦,对照组患者给予赖诺普利治疗。通过不同药物治疗来比对术前后心脏超声情况指标、治疗后临床疗效及不良反应。结果两组患者治疗后心功能指标均有所改善,观察组改善更明显(P<0.05);观察组患者治疗后临床总有效率为90.24%高于对照组70.73%(P<0.05);观察组不良反应总发生率为7.32%低于对照组26.83%(P<0.05)。结论射血分数保留心衰患者采用沙库巴曲缬沙坦治疗心脏功能、临床疗效、不良反应方面,其效果均优于赖诺普利,具有推广价值。Objective To compare the efficacy of lisinopril and sacubitril-valsartan in patients with heart failure with preserved ejection fraction.Methods From January 2020 to February 2022,82 patients with heart failure with preserved ejection fraction who were diagnosed and treated in our hospital were randomly divided into observation and control groups.There were 41 patients in both groups.The patients in the observation group were treated with sacubatrovalsartan,and the patients in the control group were treated with lisinopril.Through different drug treatments,the indexes of cardiac ultrasound before and after operation,clinical efficacy and adverse reactions after treatment were compared.Results After treatment,the indexes of cardiac function in both groups were improved,especially in the observation group(P<0.05);The total clinical effective rate in the observation group was 90.24%higher than that in the control group(70.73%,P<0.05);The total incidence of adverse reactions in the observation group was 7.32%lower than that in the control group(26.83%,P<0.05).Conclusion In the treatment of heart failure patients with preserved ejection fraction,the effect of sacubatrovalsartan is better than that of lisinopril in terms of cardiac function,clinical efficacy and adverse reactions,and it is worth popularizing.

关 键 词：赖诺普利 沙库巴曲缬沙坦 射血分数 心衰 

分 类 号：R541.6[医药卫生—心血管疾病]