骨肉瘤诱导多能干细胞模型的研究进展  

Advances in induced pluripotent stem cell models of osteosarcoma

作　　者：乔树叶 以敏[1] 李理[2] 潘思琼 陈苗玉 Shuye Qiao;Min Yi;Li Li;Siqiong Pan;Miaoyu Chen(Department of Pathology,Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Worker's Hospital,Liuzhou 545000,China;Department of Orthopaedics&Traumatology,Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Worker's Hospital,Liuzhou 545000,China)

机构地区：[1]广西医科大学第四附属医院、柳州市工人医院病理科,柳州545000 [2]广西医科大学第四附属医院、柳州市工人医院骨科,柳州545000

出　　处：《中华细胞与干细胞杂志（电子版）》2024年第1期30-36,共7页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金(82160412);广西自然科学基金(2020GXNSFBA297154);广西壮族自治区卫生健康委员会自筹项目(Z20210819);柳州市计划项目基金(2021CBB0109)。

摘　　要：骨肉瘤是一种罕见的、高度恶性的癌症,其进展迅速且具有高度侵袭性。由于早期阶段缺乏特异性症状而经常被忽视,并且被发现时常常已经转移,导致预后不良。这主要是由于对骨肉瘤发展机制的理解不足以及缺乏能够根除肿瘤的有效治疗方法。鉴于骨肉瘤发病率低,使用肿瘤模型来研究其发病和进展,以及开发新的药物和治疗方法,对于提高患者的生存率至关重要。诱导多能干细胞(iPSCs)可以用来模拟各种疾病。定向重编程和分化策略包含整个癌症的进展,并捕获疾病发病初期最早的分子变化。iPSCs具有患者特异的遗传和表观遗传特性以及分化潜能,为开发个性化癌症治疗提供新的平台。本文将回顾骨肉瘤iPSCs模型的研究进展、特性和应用。Osteosarcoma,a rare yet highly aggressive malignancy,is characterized by swift progression and potent invasiveness.Its insidious nature,owing to the absence of distinctive early symptoms,often results in late detection and subsequent metastasis,leading to a grim prognosis.The primary factors contributing to this dismal outcome are the inadequate comprehension of the underlying mechanisms of osteosarcoma and the absence of efficacious therapies to eradicate the tumor.Despite its low prevalence,tinvestigating the pathogenesis and progression and developing novel pharmaceuticals and therapeutic approaches via tumor models hold considerable significance in enhancing the survival rates of osteosarcoma patients.Induced pluripotent stem cells(iPSCs)serve as a versatile tool to model many diseases,with directed reprogramming and differentiation strategies encapsulating the entire cancer trajectory and capturing the initial molecular alterations in the disease.Endowed with both patient-specific genetic and epigenetic attributes and differentiation potential,iPSCs offer a novel platform for evolving personalized therapies for cancer patients.This article aims to provide an overview of the research advancements,model attributes,and applications of iPSCs models in osteosarcoma.

关 键 词：骨肉瘤 肿瘤模型 诱导多能干细胞 分子机制 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]