外洗一号辅助LIFT对高位单纯性肛瘘术后康复进程的影响  

Effect of external washing No.1 assisted LIFT on the postoperative rehabilitation process of high simple anal fistula

作　　者：郭洁 GUO Jie(Zhengzhou Jinshui District General Hospital,Zhengzhou 450003,Henan)

机构地区：[1]郑州市金水区总医院,河南郑州450003

出　　处：《菏泽医学专科学校学报》2024年第1期26-29,共4页Journal of Heze Medical College

摘　　要：目的 研究外洗一号辅助经括约肌间瘘管结扎术(LIFT)对高位单纯性肛瘘术后康复进程的影响。方法 选择我院收治的118例高位单纯性肛瘘患者为研究对象,采用随机数字表法分为对照组和观察组,每组59例。两组均给予LIFT治疗,对照组术后给予常规西药治疗,观察组在对照组基础上加用外洗一号辅助治疗。比较两组临床疗效、创面愈合时间、上皮生长时间、脓苔脱落时间、术后1 d、术后14 d创面疼痛视觉模拟评分(VAS)、创面水肿评分、创面渗液量、肛肠动力学指标[肛管最大收缩压(AMCP)、直肠静息压(RRP)、肛管静息压(ARP)]、血清细胞因子[纤维连接蛋白(FN)、表皮生长因子(EGF)、8-羟基脱氧鸟苷(8-OHDG)]水平。结果 两组临床疗效比较,P<0.05;观察组创面愈合时间、上皮生长时间、脓苔脱落时间均短于对照组(P<0.05);术后14 d,观察组VAS评分、创面水肿评分及创面渗液量低于对照组(P<0.05);观察组AMCP、RRP、ARP低于对照组(P<0.05);观察组血清FN、EGF水平高于对照组,8-OHDG水平低于对照组(P<0.05)。结论 采用外洗一号辅助LIFT治疗高位单纯性肛瘘患者可显著提高临床疗效,减轻氧化应激性损伤及疼痛,加速创面愈合,促进肛肠动力学改善。Objective To explore the effect of external washing No.1 assisted ligation of intersphincteric fistula tr act(LIFT)on the postoperative rehabilitation process of high simple anal fistula.Methods A total of 118 patients with high simple anal fistula admitted to our hospital were selected as the research objects,and were randomly divided into the control group and the observation group,59 cases in each group.The two groups were given LIFT treatment,the control group was given conventional western medicine after surgery,and the observation group was given external washing No.1 adjuvant treatment on the basis of the control group.The clinical efficacy,wound healing time,epithelial growth time,pus coating detachment time were compared between the two groups,as well as the visual analogue score(VAS)of wound pain,wound edema score,wound exudate volume,anal motility indicators[anal maximum contraction pressure(AMCP),rectal resting pressure(RRP),anal rest perssure(ARP)],and serum cytokine[Fibronectin(FN),epidermal growth factor(EGF),8-hydroxydeoxyguanosine(8-OHDG)]levels 1d and 14d after surgery were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The wound healing time,epithelial growth time and pus moss shedding time in the observation group were shorter than those in the control group(P<0.05).14 day after surgery,the VAS score,wound edema score and wound fluid seepage volume of the observation group were lower than those of the control group(P<0.05);the AMCP,RRP and ARP in the observation group were lower than those in the control group(P<0.05);the serum FN and EGF levels in the observation group were higher than those in the control group,and the serum 8-OHDG levels were lower than those in the control group(P<0.05).Conclusion The use of external washing No.1 assisted LIFT in the treatment of patients with high simple anal fistula can significantly improve clinical efficacy,reduce oxidative stress injury and pain,accelerate wou

关 键 词：外洗一号 经括约肌间瘘管结扎术 单纯性肛瘘 康复 

分 类 号：R657.16[医药卫生—外科学]