肥胖型支气管哮喘与脂质代谢相关作用机制及研究进展  

Mechanisms and research progress on the interplay between obesity-associated bronchial asthma and lipid metabolism

作　　者：张凤芹 刘辉国[1] Zhang Fengqin;Liu Huiguo(Department of Respiratory and Critical Care Medicine,National Health Commission Key Laboratory of Pulmonary Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Sciences and Technology,Wuhan 430000,China)

机构地区：[1]华中科技大学同济医学院附属同济医院呼吸与危重症医学科/国家卫生健康委员会呼吸疾病重点实验室,武汉430000

出　　处：《国际呼吸杂志》2024年第2期241-245,共5页International Journal of Respiration

基　　金：国家自然科学基金(82270104)。

摘　　要：支气管哮喘(哮喘)是一种常见的慢性异质性气道炎症疾病,气道高反应性和可逆性气道阻塞及气道重塑是其主要病理特征。肥胖作为体内脂肪过多沉积引起的代谢疾病,已成为不可忽视的全球公共卫生问题。随着肥胖人口的不断增加,肥胖型哮喘的患病率也呈逐年上升趋势。2014年全球哮喘防治倡议指南已将肥胖型哮喘作为一种新的哮喘表型。肥胖是一种典型的脂质代谢相关疾病,近年研究发现哮喘的发生发展与脂质代谢有一定的关联。本文将讨论脂质代谢在肥胖相关哮喘发生发展中的作用。Bronchial asthma(asthma)is a prevalent chronic heterogeneous airway inflammatory disease characterized by airway hyperresponsiveness.Reversible airway obstruction and airway remodeling are the primary pathological features.Obesity,a metabolic disorder resulting from excessive accumulation of body fat,has evolved into an undeniable global public health concern.With the continuous growth of obese population,the prevalence of obesity-related asthma has been increasing year by year.In 2014,the Global Initiative for Asthma guidelines recognized obesity-related asthma as a new asthma phenotype.Obesity is a typical lipid metabolism-related disorder,and recent research has unveiled an association between lipid metabolism and the initiation and progression of asthma.This article will explore the role of lipid metabolism in the initiation and progression of obesity-related asthma.

关 键 词：哮喘 肥胖 脂质代谢 

分 类 号：R562.25[医药卫生—呼吸系统]